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Literature summary extracted from

  • Atlante, A.; de Bari, L.; Bobba, A.; Marra, E.; Passarella, S.
    Transport and metabolism of L-lactate occur in mitochondria from cerebellar granule cells and are modified in cells undergoing low potassium dependent apoptosis (2007), Biochim. Biophys. Acta, 1767, 1285-1299.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.27 ADP
-
 Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.27 oxamate specific inhibitor of L-LDH Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.27 mitochondrion inner compartment, transport and metabolism of L-lactate, overview Bos taurus 5739
-
1.1.1.27 additional information immunohistochemic analysis of subcellular localization Bos taurus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.27 (S)-lactate + NAD(P)+ Bos taurus L-lactate transport and metabolism, regulation and localization of enzyme participating in the pathway, overview pyruvate + NAD(P)H + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.27 Bos taurus
-
 calf
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.27 cerebellum
-
 Bos taurus
-
1.1.1.27 commercial preparation
-
 Bos taurus
-
1.1.1.27 granule cell cerebellar Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.27 (S)-lactate + NAD(P)+
-
 Bos taurus pyruvate + NAD(P)H + H+
-
 r
1.1.1.27 (S)-lactate + NAD(P)+ L-lactate transport and metabolism, regulation and localization of enzyme participating in the pathway, overview Bos taurus pyruvate + NAD(P)H + H+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.27 L-LDH
-
 Bos taurus
1.1.1.27 mLDH
-
 Bos taurus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.27 25
-
 assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.27 7.6
-
 assay at Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.27 NAD+
-
 Bos taurus
1.1.1.27 NADH
-
 Bos taurus
1.1.1.27 NADP+
-
 Bos taurus
1.1.1.27 NADPH
-
 Bos taurus