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Literature summary extracted from

  • Cherry, J.A.; Thompson, B.E.; Pho, V.
    Diazepam and rolipram differentially inhibit cyclic AMP-specific phosphodiesterases PDE4A1 and PDE4B3 in the mouse (2001), Biochim. Biophys. Acta, 1518, 27-35.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.53
-
 Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.53 diazepam
-
 Mus musculus
3.1.4.53 isobutylmethylxanthine 0.1 mM, 14% inhibition; 0.1 mM, 32% inhibition Mus musculus
3.1.4.53 Milrinone 0.1 mM, 93% inhibition Mus musculus
3.1.4.53 Ro 20-1724 0.1 mM, 12% inhibition; 0.1 mM, 4% inhibition Mus musculus
3.1.4.53 rolipram 0.1 mM, 4% inhibition; 0.1 mM, 7% inhibition Mus musculus
3.1.4.53 zaprinast 0.1 mM, 67% inhibition; 0.1 mM, 72% inhibition Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.53 0.007
-
 adenosine 3',5'-cyclic phosphate
-
 Mus musculus
3.1.4.53 0.0092
-
 adenosine 3',5'-cyclic phosphate
-
 Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.4.53 83000
-
 x * 83000, SDS-PAGE Mus musculus
3.1.4.53 93000
-
 x * 93000, SDS-PAGE Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.53 Mus musculus O89084
-
-
3.1.4.53 Mus musculus Q9QXI7
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.53 adenosine 3',5'-cyclic phosphate + H2O
-
 Mus musculus adenosine 5'-phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.4.53 ? x * 83000, SDS-PAGE Mus musculus
3.1.4.53 ? x * 93000, SDS-PAGE Mus musculus

Synonyms

EC Number Synonyms Comment Organism
3.1.4.53 PDE4A1
-
 Mus musculus
3.1.4.53 PDE4B3
-
 Mus musculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.4.53 0.0183
-
 diazepam
-
 Mus musculus
3.1.4.53 0.0493
-
 diazepam
-
 Mus musculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.4.53 0.00017
-
-
 Mus musculus rolipram
3.1.4.53 0.0011
-
-
 Mus musculus rolipram
3.1.4.53 0.0094
-
-
 Mus musculus diazepam
3.1.4.53 0.043
-
-
 Mus musculus diazepam