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Literature summary extracted from

  • Tamta, H.; Kalra, S.; Thilagavathi, R.; Chakraborti, A.K.; Mukhopadhyay, A.K.
    Nature and position of functional group on thiopurine substrates influence activity of xanthine oxidase - enzymatic reaction pathways of 6-mercaptopurine and 2-mercaptopurine are different (2007), Biochemistry (Moscow), 72, 170-177.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.17.3.2 0.00046
-
 6-Thioxanthine 25°C Bos taurus
1.17.3.2 0.00047
-
 2-Thioxanthine 25°C Bos taurus
1.17.3.2 0.00088
-
 2-mercaptopurine 25°C Bos taurus
1.17.3.2 0.002
-
 6-Mercaptopurine 25°C Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.3.2 xanthine + H2O + O2 Bos taurus
-
 urate + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.3.2 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.3.2 milk
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.3.2 2-mercaptopurine + H2O + O2 no conversion to 2-thioxanthine Bos taurus 8-hydroxy-2-mercaptopurine + H2O2
-
 ?
1.17.3.2 2-thioxanthine + H2O + O2
-
 Bos taurus 2-thiouric acid + H2O2
-
 ?
1.17.3.2 6-mercaptopurine + 2 H2O + 2 O2 a two-step reaction with 6-thioxanthine as intermediate Bos taurus 6-thiouric acid + 2 H2O2
-
 ?
1.17.3.2 6-thioxanthine + H2O + O2
-
 Bos taurus 6-thiouric acid + H2O2
-
 ?
1.17.3.2 hypoxanthine + 2 H2O + 2 O2 a two-step reaction with xanthine as intermediate, production of superoxide radicals Bos taurus urate + 2 H2O2
-
 ?
1.17.3.2 additional information nature and position of functional group on thiopurine substrates influence activity of xanthine oxidase Bos taurus ?
-
 ?
1.17.3.2 xanthine + H2O + O2
-
 Bos taurus urate + H2O2
-
 ?
1.17.3.2 xanthine + H2O + O2 production of superoxide radicals Bos taurus urate + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.17.3.2 XOD
-
 Bos taurus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.17.3.2 25
-
 assay at Bos taurus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.17.3.2 0.13
-
 6-Mercaptopurine 25°C Bos taurus
1.17.3.2 1.98
-
 2-mercaptopurine 25°C Bos taurus
1.17.3.2 2.76
-
 6-Thioxanthine 25°C Bos taurus
1.17.3.2 3.32
-
 2-Thioxanthine 25°C Bos taurus