Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Boulatnikov, I.G.; Nadeau, O.W.; Daniels, P.J.; Sage, J.M.; Jeyasingham, M.D.; Villar, M.T.; Artigues, A.; Carlson, G.M.
    The regulatory beta subunit of phosphorylase kinase interacts with glyceraldehyde-3-phosphate dehydrogenase (2008), Biochemistry, 47, 7228-7236.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.19 alpha, gamma, delta-trimer, complex is shown to be unable to phosphorylate glyceraldehyde-3-phosphate dehydrogenase Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.19 glyceraldehyde-3-phosphate dehydrogenase
-
 Mus musculus
2.7.11.19 glyceraldehyde-3-phosphate dehydrogenase
-
 Oryctolagus cuniculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.19 Ca2+ Ca2+-dependent reaction Mus musculus
2.7.11.19 Ca2+ Ca2+-dependent reaction Oryctolagus cuniculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.11.19 16700
-
 alpha,beta, gamma,delta, 4 * 138400 + 4 * 125200 + 4 * 44700 + 4 * 16700, catalytic gamma subunit is controlled by its regulatory alpha and beta, and delta subunits, delta subunit is calmodulin Mus musculus
2.7.11.19 16700
-
 alpha,beta, gamma,delta, 4 * 138400 + 4 * 125200 + 4 * 44700 + 4 * 16700, catalytic gamma subunit is controlled by its regulatory alpha and beta, and delta subunits, delta subunit is calmodulin Oryctolagus cuniculus
2.7.11.19 44700
-
 alpha,beta, gamma,delta, 4 * 138400 + 4 * 125200 + 4 * 44700 + 4 * 16700, catalytic gamma subunit is controlled by its regulatory alpha and beta, and delta subunits, delta subunit is calmodulin Mus musculus
2.7.11.19 44700
-
 alpha,beta, gamma,delta, 4 * 138400 + 4 * 125200 + 4 * 44700 + 4 * 16700, catalytic gamma subunit is controlled by its regulatory alpha and beta, and delta subunits, delta subunit is calmodulin Oryctolagus cuniculus
2.7.11.19 125200
-
 alpha,beta, gamma,delta, 4 * 138400 + 4 * 125200 + 4 * 44700 + 4 * 16700, catalytic gamma subunit is controlled by its regulatory alpha and beta, and delta subunits, delta subunit is calmodulin Mus musculus
2.7.11.19 125200
-
 alpha,beta, gamma,delta, 4 * 138400 + 4 * 125200 + 4 * 44700 + 4 * 16700, catalytic gamma subunit is controlled by its regulatory alpha and beta, and delta subunits, delta subunit is calmodulin Oryctolagus cuniculus
2.7.11.19 138400
-
 alpha,beta, gamma,delta, 4 * 138400 + 4 * 125200 + 4 * 44700 + 4 * 16700, catalytic gamma subunit is controlled by its regulatory alpha and beta, and delta subunits, delta subunit is calmodulin Mus musculus
2.7.11.19 138400
-
 alpha,beta, gamma,delta, 4 * 138400 + 4 * 125200 + 4 * 44700 + 4 * 16700, catalytic gamma subunit is controlled by its regulatory alpha and beta, and delta subunits, delta subunit is calmodulin Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.19 glycogen phosphorylase b + ATP Mus musculus phosphorylates and activates glycogen phosphorylase b, couples muscle contraction with glycogen breakdown glycogen phosphorylase a + ADP
-
 ?
2.7.11.19 glycogen phosphorylase b + ATP Oryctolagus cuniculus phosphorylates and activates glycogen phosphorylase b, couples muscle contraction with glycogen breakdown glycogen phosphorylase a + ADP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.12 Mus musculus
-
-
-
2.7.11.19 Mus musculus
-
-
-
2.7.11.19 Oryctolagus cuniculus
-
 New Zealand white rabbit
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.19
-
 Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.12 skeletal muscle
-
 Mus musculus
-
2.7.11.19 muscle psoas muscle Oryctolagus cuniculus
-
2.7.11.19 skeletal muscle from back and leg Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.12 additional information GAPDH is a Ca2+-dependent substrate of phosphorylase kinase although the rate of phosphorylation is very slow Mus musculus ?
-
 ?
2.7.11.19 glyceraldehyde-3-phosphate dehydrogenase + ATP phosphorylation is very slow, binds tightly to enzyme and acts as inhibitor for the phosphorylation of glycogen phosphorylase b Mus musculus ?
-
 ?
2.7.11.19 glyceraldehyde-3-phosphate dehydrogenase + ATP phosphorylation is very slow, binds tightly to enzyme and acts as inhibitor for the phosphorylation of glycogen phosphorylase b Oryctolagus cuniculus ?
-
 ?
2.7.11.19 glycogen phosphorylase b + ATP
-
 Mus musculus glycogen phosphorylase a + ADP
-
 ?
2.7.11.19 glycogen phosphorylase b + ATP
-
 Oryctolagus cuniculus glycogen phosphorylase a + ADP
-
 ?
2.7.11.19 glycogen phosphorylase b + ATP phosphorylates and activates glycogen phosphorylase b, couples muscle contraction with glycogen breakdown Mus musculus glycogen phosphorylase a + ADP
-
 ?
2.7.11.19 glycogen phosphorylase b + ATP phosphorylates and activates glycogen phosphorylase b, couples muscle contraction with glycogen breakdown Oryctolagus cuniculus glycogen phosphorylase a + ADP
-
 ?
2.7.11.19 SDQEKRKQISVRGL + ATP artificial substrate Oryctolagus cuniculus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.19 hexadecamer alpha,beta, gamma,delta, 4 * 138400 + 4 * 125200 + 4 * 44700 + 4 * 16700, catalytic gamma subunit is controlled by its regulatory alpha and beta, and delta subunits, delta subunit is calmodulin Mus musculus
2.7.11.19 hexadecamer alpha,beta, gamma,delta, 4 * 138400 + 4 * 125200 + 4 * 44700 + 4 * 16700, catalytic gamma subunit is controlled by its regulatory alpha and beta, and delta subunits, delta subunit is calmodulin Oryctolagus cuniculus

Synonyms

EC Number Synonyms Comment Organism
1.2.1.12 D-glyceraldehyde-3-phosphate dehydrogenase
-
 Mus musculus
1.2.1.12 GAPDH
-
 Mus musculus
2.7.11.19 EC 2.7.1.38 formerly, transferred to EC 2.7.11.19 Mus musculus
2.7.11.19 EC 2.7.1.38 formerly, transferred to EC 2.7.11.19 Oryctolagus cuniculus
2.7.11.19 PhK
-
 Mus musculus
2.7.11.19 PhK
-
 Oryctolagus cuniculus
2.7.11.19 Phosphorylase b kinase
-
 Mus musculus
2.7.11.19 Phosphorylase b kinase
-
 Oryctolagus cuniculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.11.19 0.00045
-
-
 Oryctolagus cuniculus glyceraldehyde-3-phosphate dehydrogenase