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Literature summary extracted from

  • Basran, J.; Rafice, S.A.; Chauhan, N.; Efimov, I.; Cheesman, M.R.; Ghamsari, L.; Raven, E.L.
    A kinetic, spectroscopic, and redox study of human tryptophan 2,3-dioxygenase (2008), Biochemistry, 47, 4752-4760.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.13.11.52 expression in Escherichia coli as a full-length, C-terminal hexahistidine fusion protein Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.13.11.52 0.006
-
 5-fluoro-tryptophan
-
 Homo sapiens
1.13.11.52 0.007
-
 L-tryptophan
-
 Homo sapiens
1.13.11.52 0.017
-
 5-hydroxy-tryptophan
-
 Homo sapiens
1.13.11.52 0.098
-
 5-methyl-tryptophan
-
 Homo sapiens
1.13.11.52 0.222
-
 L-tryptophan
-
 Homo sapiens
1.13.11.52 0.36
-
 5-fluoro-tryptophan
-
 Homo sapiens
1.13.11.52 1.57
-
 D-tryptophan
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.52 Homo sapiens
-
-
-
1.13.11.52 Homo sapiens P48775
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.13.11.52
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.52 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.52 5-fluoro-tryptophan + O2
-
 Homo sapiens 4-(2-amino-5-fluorophenyl)-2-(formylamino)-4-oxobutanoic acid
-
 ?
1.13.11.52 5-fluoro-tryptophan + O2
-
 Homo sapiens ?
-
 ?
1.13.11.52 5-hydroxy-tryptophan + O2
-
 Homo sapiens 4-(2-amino-5-hydroxyphenyl)-2-(formylamino)-4-oxobutanoic acid
-
 ?
1.13.11.52 5-methyl-tryptophan + O2
-
 Homo sapiens 4-(2-amino-5-methylphenyl)-2-(formylamino)-4-oxobutanoic acid
-
 ?
1.13.11.52 D-tryptophan + O2
-
 Homo sapiens N-formyl-D-kynurenine
-
 ?
1.13.11.52 L-tryptophan + O2
-
 Homo sapiens N-formyl-L-kynurenine
-
 ?
1.13.11.52 L-tryptophan + O2 no activity with D-tryptophan Homo sapiens N-formyl-L-kynurenine
-
 ?
1.13.11.52 additional information no activity with tryptophanol, indole-3-propionic acid, tryptamine, N-methyl-Trp Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.52 hIDO
-
 Homo sapiens
1.13.11.52 hTDO
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.13.11.52 0.025
-
 5-hydroxy-tryptophan
-
 Homo sapiens
1.13.11.52 0.18
-
 5-fluoro-tryptophan
-
 Homo sapiens
1.13.11.52 0.76
-
 5-fluoro-tryptophan
-
 Homo sapiens
1.13.11.52 1.4
-
 L-tryptophan
-
 Homo sapiens
1.13.11.52 3.78
-
 5-methyl-tryptophan
-
 Homo sapiens
1.13.11.52 3.93
-
 D-tryptophan
-
 Homo sapiens