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Literature summary extracted from

  • Applegate, M.A.; Humphries, K.M.; Szweda, L.I.
    Reversible inhibition of alpha-ketoglutarate dehydrogenase by hydrogen peroxide: glutathionylation and protection of lipoic acid (2008), Biochemistry, 47, 473-478.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.105 hydrogen peroxide the E2 subunit of alpha-ketoglutarate dehydrogenase is reversibly glutathionylated and inhibited by 0.025 mM hydrogen peroxide, the enzyme is maximally inhibited (about 45%) 5.0 min after the addition of H2O2 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.105 mitochondrion
-
 Rattus norvegicus 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.1.105 50000
-
 SDS-PAGE Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.105 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.105 heart
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.105 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
-
 Rattus norvegicus [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.105 alpha-ketoglutarate dehydrogenase
-
 Rattus norvegicus
1.2.1.105 KGDH KGDH is a multienzyme complex that consists of multiple copies of three subunits: E1 (alpha-ketoacid decarboxylase), E2(dihydrolipoyl transacetylase), and E3 (dihydrolipoamide dehydrogenase) Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.105 thiamine diphosphate
-
 Rattus norvegicus