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Literature summary extracted from

  • Saunders, A.H.; Griffiths, A.E.; Lee, K.H.; Cicchillo, R.M.; Tu, L.; Stromberg, J.A.; Krebs, C.; Booker, S.J.
    Characterization of quinolinate synthases from Escherichia coli, Mycobacterium tuberculosis, and Pyrococcus horikoshii indicates that [4Fe-4S] clusters are common cofactors throughout this class of enzymes (2008), Biochemistry, 47, 10999-11012.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.72
-
Escherichia coli
2.5.1.72
-
Mycobacterium tuberculosis
2.5.1.72
-
Pyrococcus horikoshii

Protein Variants

EC Number Protein Variants Comment Organism
2.5.1.72 C113A 0.8 iron ions per polypeptide, no catalytic activity Escherichia coli
2.5.1.72 C113S 1.3 iron ions per polypeptide, no catalytic activity Escherichia coli
2.5.1.72 C119S 1.0 iron ions per polypeptide Escherichia coli
2.5.1.72 C128S 2.7 iron ions per polypeptide Escherichia coli
2.5.1.72 C195S 1.5 iron ions per polypeptide Escherichia coli
2.5.1.72 C200A 1.5 iron ions per polypeptide, no catalytic activity Escherichia coli
2.5.1.72 C200S 1.0 iron ions per polypeptide, no catalytic activity Escherichia coli
2.5.1.72 C291S 0.8 iron ions per polypeptide Escherichia coli
2.5.1.72 C294S 2.1 iron ions per polypeptide Escherichia coli
2.5.1.72 C297A 0.3 iron ions per polypeptide, no catalytic activity Escherichia coli
2.5.1.72 C297S 0.3 iron ions per polypeptide, no catalytic activity Escherichia coli
2.5.1.72 C64S 1.4 iron ions per polypeptide Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.5.1.72 Iron protein contains a [4Fe-4S] cluster absolutely required for activity Mycobacterium tuberculosis
2.5.1.72 Iron protein contains a [4Fe-4S] cluster absolutely required for activity Pyrococcus horikoshii
2.5.1.72 Iron protein contains a [4Fe-4S] cluster absolutely required for activity. 3 iron ions per polypeptide Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.72 Escherichia coli
-
-
-
2.5.1.72 Mycobacterium tuberculosis
-
-
-
2.5.1.72 Pyrococcus horikoshii
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.72
-
Escherichia coli
2.5.1.72
-
Mycobacterium tuberculosis
2.5.1.72
-
Pyrococcus horikoshii

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.72 dihydroxyacetone phosphate + iminoaspartate
-
Escherichia coli ? + H2O + phosphate
-
?
2.5.1.72 dihydroxyacetone phosphate + iminoaspartate
-
Mycobacterium tuberculosis ? + H2O + phosphate
-
?
2.5.1.72 dihydroxyacetone phosphate + iminoaspartate
-
Pyrococcus horikoshii ? + H2O + phosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.72 NadA
-
Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
2.5.1.72 iron-sulfur centre protein contains a [4Fe-4S] cluster absolutely required for activity Escherichia coli
2.5.1.72 iron-sulfur centre protein contains a [4Fe-4S] cluster absolutely required for activity Mycobacterium tuberculosis
2.5.1.72 iron-sulfur centre protein contains a [4Fe-4S] cluster absolutely required for activity Pyrococcus horikoshii