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Literature summary extracted from

  • Gradinaru, R.; Schowen, R.; Ghisla, S.
    Solvent isotope effects in reactions of human medium-chain acyl-CoA dehydrogenase active site mutants (2007), Biochemistry, 46, 2497-2509.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.3.8.7 E376G the rate of dehydrogenation is lowered by approximately 5 orders of magnitude Homo sapiens
1.3.8.7 E376Q the rate of dehydrogenation is lowered by 4-5 orders of magnitude Homo sapiens
1.3.8.7 E376Q/E99G the rate of dehydrogenation is lowered by 4-5 orders of magnitude Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.3.8.7 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.8.7 acyl-CoA + acceptor
-
 Homo sapiens 2,3-dehydroacyl-CoA + reduced acceptor
-
 ?
1.3.8.7 octanoyl-CoA + acceptor
-
 Homo sapiens 2-octenoyl-CoA + reduced acceptor
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.8.7 MCAD
-
 Homo sapiens
1.3.8.7 medium-chain acyl-CoA dehydrogenase
-
 Homo sapiens

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.3.8.7 25
-
 mutant enzyme E376Q is instable at 25°C Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.8.7 FAD
-
 Homo sapiens