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Literature summary extracted from

  • Hartman, M.C.; Jiang, S.; Rush, J.S.; Waechter, C.J.; Coward, J.K.
    Glycosyltransferase mechanisms: impact of a 5-fluoro substituent in acceptor and donor substrates on catalysis (2007), Biochemistry, 46, 11630-11638.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.141 5-fluoro N-acetylglucosamine
-
 Cricetulus griseus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.141 0.392
-
 UDP-N-acetyl-D-glucosamine
-
 Cricetulus griseus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.141 microsome
-
 Cricetulus griseus
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.141 Cricetulus griseus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.141 partial Cricetulus griseus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.141 CHO cell
-
 Cricetulus griseus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.141 additional information 5-fluoro N-acetylglucosamine is completely inactive as a glycosyl donor Cricetulus griseus ?
-
 ?
2.4.1.141 UDP-N-acetyl-alpha-D-glucosamine + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
 Cricetulus griseus UDP + N,N'-diacetylchitobiosyl-diphosphodolichol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.141 chitobiosyl-PP-lipid synthase
-
 Cricetulus griseus
2.4.1.141 CLS
-
 Cricetulus griseus
2.4.1.141 UDP-GlcNAc:GlcNAc-P-P-Dol N-acetylglucosaminyltransferase
-
 Cricetulus griseus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.4.1.141 1.25
-
-
 Cricetulus griseus 5-fluoro N-acetylglucosamine