EC Number | Cloned (Comment) | Organism |
---|---|---|
1.8.1.B1 | recombinant TGR is mostly insoluble when expressed in Escherichi coli, and neither cloning of the enzyme that contain various tags nor coexpression of TGR with chaperones increases its solubility | Mus musculus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.8.1.B1 | additional information | - |
additional information | kinetic properties of the Grx domain of TGR | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.8.1.B1 | Bos taurus | - |
- |
- |
1.8.1.B1 | Danio rerio | - |
- |
- |
1.8.1.B1 | Gallus gallus | - |
- |
- |
1.8.1.B1 | Homo sapiens | - |
- |
- |
1.8.1.B1 | Mus musculus | - |
- |
- |
1.8.1.B1 | no activity in Caenorhabditis elegans | - |
- |
- |
1.8.1.B1 | no activity in Canis familiaris | - |
- |
- |
1.8.1.B1 | no activity in Drosophila melanogaster | - |
- |
- |
1.8.1.B1 | no activity in Sus scrofa | - |
- |
- |
1.8.1.B1 | Pan troglodytes | - |
- |
- |
1.8.1.B1 | Rattus norvegicus | - |
- |
- |
1.8.1.B1 | Takifugu rubripes | - |
- |
- |
1.8.1.B1 | Tetraodon nigroviridis | - |
- |
- |
1.8.1.B1 | Xenopus laevis | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.8.1.B1 | small amounts of the soluble enzyme are obtained by purifying it from a large quantity of cells, in which protein synthesis is induced slowly for a period of 24 h at a low temperature | Mus musculus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.8.1.B1 | liver | TGR is regulated by both selenium availability and selenocysteine tRNA status. This regulation is more pronounced in liver, whereas in testes, the expression level is only slightly affected | Mus musculus | - |
1.8.1.B1 | testis | TGR is regulated by both selenium availability and selenocysteine tRNA status. This regulation is more pronounced in liver, whereas in testes, the expression level is only slightly affected | Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.8.1.B1 | 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+ | - |
Mus musculus | ? | - |
? | |
1.8.1.B1 | glutathione disulfide + NADPH + H+ | - |
Mus musculus | glutathione + NADP+ | - |
? | |
1.8.1.B1 | thioredoxin disulfide + NADPH + H+ | - |
Mus musculus | thioredoxin + NADP+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.8.1.B1 | TGR | - |
Gallus gallus |
1.8.1.B1 | TGR | - |
Mus musculus |
1.8.1.B1 | TGR | - |
Homo sapiens |
1.8.1.B1 | TGR | - |
Rattus norvegicus |
1.8.1.B1 | TGR | - |
Bos taurus |
1.8.1.B1 | TGR | - |
Xenopus laevis |
1.8.1.B1 | TGR | - |
Danio rerio |
1.8.1.B1 | TGR | - |
Pan troglodytes |
1.8.1.B1 | TGR | - |
Takifugu rubripes |
1.8.1.B1 | TGR | - |
Tetraodon nigroviridis |
1.8.1.B1 | thioredoxin/glutathione reductase | - |
Gallus gallus |
1.8.1.B1 | thioredoxin/glutathione reductase | - |
Mus musculus |
1.8.1.B1 | thioredoxin/glutathione reductase | - |
Homo sapiens |
1.8.1.B1 | thioredoxin/glutathione reductase | - |
Rattus norvegicus |
1.8.1.B1 | thioredoxin/glutathione reductase | - |
Bos taurus |
1.8.1.B1 | thioredoxin/glutathione reductase | - |
Xenopus laevis |
1.8.1.B1 | thioredoxin/glutathione reductase | - |
Danio rerio |
1.8.1.B1 | thioredoxin/glutathione reductase | - |
Pan troglodytes |
1.8.1.B1 | thioredoxin/glutathione reductase | - |
Takifugu rubripes |
1.8.1.B1 | thioredoxin/glutathione reductase | - |
Tetraodon nigroviridis |