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Literature summary extracted from

  • Perez-Zuniga, F.J.; Guenther Sillero, M.A.; Sillero, A.
    Bisphosphonates activate the 5-fluorouracil/uracil phosphoribosyltransferase activity present in Saccharomyces cerevisiae cell extracts: implications for tumor treatments (2008), Biochem. Pharmacol., 76, 825-830.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.2.9 alendronate 1 mM, increases the initial rate of synthesis of 5-fluoro-UMP 2.5fold, increases the initial rate of synthesis of UMP 2.3fold Saccharomyces cerevisiae
2.4.2.9 clodronate 1 mM, increases the initial rate of synthesis of 5-fluoro-UMP 2fold, increases the initial rate of synthesis of UMP 1.9fold Saccharomyces cerevisiae
2.4.2.9 etidronate 1 mM, increases the initial rate of synthesis of 5-fluoro-UMP 2.8fold, increases the initial rate of synthesis of UMP 2.1fold Saccharomyces cerevisiae
2.4.2.9 additional information no activating effect with methylene biphosphonate Saccharomyces cerevisiae
2.4.2.9 pamidronate 1 mM, increases the initial rate of synthesis of 5-fluoro-UMP 2.6fold, increases the initial rate of synthesis of UMP 2.1fold Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.9 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.9 5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Saccharomyces cerevisiae 5-fluoro-UMP + diphosphate
-
 ?
2.4.2.9 uracil + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Saccharomyces cerevisiae UMP + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.9 UPRT
-
 Saccharomyces cerevisiae