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Literature summary extracted from

  • Kawamura, A.; Westwood, I.; Wakefield, L.; Long, H.; Zhang, N.; Walters, K.; Redfield, C.; Sim, E.
    Mouse N-acetyltransferase type 2, the homologue of human N-acetyltransferase type 1 (2008), Biochem. Pharmacol., 75, 1550-1560.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.5 expressed in Escherichia coli as a His-tagged fusion protein Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.5 17-hydroxy-beta-estradiol
-
 Mus musculus
2.3.1.5 17-hydroxy-progesterone
-
 Mus musculus
2.3.1.5 4-hydroxy tamoxifen
-
 Mus musculus
2.3.1.5 alpha-zearalenol
-
 Mus musculus
2.3.1.5 androstenedione
-
 Mus musculus
2.3.1.5 beta-zearalenol
-
 Mus musculus
2.3.1.5 bisphenol A
-
 Mus musculus
2.3.1.5 diethylstilbestrol
-
 Mus musculus
2.3.1.5 estrone
-
 Mus musculus
2.3.1.5 genistein
-
 Mus musculus
2.3.1.5 pregnenolone
-
 Mus musculus
2.3.1.5 tamoxifen
-
 Mus musculus
2.3.1.5 testosterone
-
 Mus musculus
2.3.1.5 zearalenone
-
 Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.5 34000
-
 molecular weight of His-tagged fusion protein, determined by SDS-PAGE Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.5 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.5 using Ni-NTA chromatography Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.5 28
-
 thrombin cleaved fusion protein Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.5 acetyl-CoA + 2-aminofluorene high specific activity Mus musculus CoA + N-acetyl-2-aminofluorene
-
 ?
2.3.1.5 acetyl-CoA + 4-aminobenzoic acid high specific activity Mus musculus CoA + N-acetyl-4-aminobenzoic acid
-
 ?
2.3.1.5 acetyl-CoA + 4-aminobenzoyl-L-glutamate
-
 Mus musculus CoA + N-acetyl-4-aminobenzoyl-L-glutamate
-
 ?
2.3.1.5 acetyl-CoA + 4-aminopyridine
-
 Mus musculus CoA + N-acetyl-4-aminopyridine
-
 ?
2.3.1.5 acetyl-CoA + 4-aminosalicylic acid high specific activity Mus musculus CoA + N-acetyl-4-aminosalicylic acid
-
 ?
2.3.1.5 acetyl-CoA + 4-aminoveratrole
-
 Mus musculus CoA + N-acetyl-4-aminoveratrole
-
 ?
2.3.1.5 acetyl-CoA + 4-bromoaniline
-
 Mus musculus CoA + N-acetyl-4-bromoaniline
-
 ?
2.3.1.5 acetyl-CoA + 4-butoxyaniline
-
 Mus musculus CoA + N-acetyl-4-butoxyaniline
-
 ?
2.3.1.5 acetyl-CoA + 4-chloroaniline
-
 Mus musculus CoA + N-acetyl-4-chloroaniline
-
 ?
2.3.1.5 acetyl-CoA + 4-ethoxyaniline
-
 Mus musculus CoA + N-acetyl-4-ethoxyaniline
-
 ?
2.3.1.5 acetyl-CoA + 4-hexyloxyaniline
-
 Mus musculus CoA + N-acetyl-4-hexyloxyaniline
-
 ?
2.3.1.5 acetyl-CoA + 4-iodoaniline
-
 Mus musculus CoA + N-acetyl-4-iodoaniline
-
 ?
2.3.1.5 acetyl-CoA + 4-methoxyaniline
-
 Mus musculus CoA + N-acetyl-4-methoxyaniline
-
 ?
2.3.1.5 acetyl-CoA + 4-phenoxyaniline
-
 Mus musculus CoA + N-acetyl-4-phenoxyaniline
-
 ?
2.3.1.5 acetyl-CoA + 5-aminosalicylic acid high specific activity Mus musculus CoA + N-acetyl-5-aminosalicylic acid
-
 ?
2.3.1.5 acetyl-CoA + aniline
-
 Mus musculus CoA + N-acetyl-aniline
-
 ?
2.3.1.5 acetyl-CoA + hydralazine low specific activity Mus musculus CoA + N-acetyl-hydralazine
-
 ?
2.3.1.5 acetyl-CoA + isoniazid low specific activity Mus musculus CoA + N-acetyl-isoniazid
-
 ?
2.3.1.5 acetyl-CoA + phenylhydrazine low specific activity Mus musculus CoA + N-acetyl-phenylhydrazine
-
 ?
2.3.1.5 acetyl-CoA + procainamide low specific activity Mus musculus CoA + N-acetyl- procainamide
-
 ?
2.3.1.5 acetyl-CoA + sulfamethazine low specific activity Mus musculus CoA + N-acetyl-sulfamethazine
-
 ?
2.3.1.5 additional information mouse Nat2 is very similar to human NAT1 in substrate specificity Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.5 N-acetyltransferase type 2
-
 Mus musculus
2.3.1.5 NAT2
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.5 25
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.5 8
-
 assay at Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.5 acetyl-CoA
-
 Mus musculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.5 0.045
-
-
 Mus musculus genistein
2.3.1.5 0.05
-
-
 Mus musculus diethylstilbestrol
2.3.1.5 0.055
-
-
 Mus musculus 17-hydroxy-beta-estradiol
2.3.1.5 0.057
-
-
 Mus musculus tamoxifen
2.3.1.5 0.065
-
-
 Mus musculus 4-OH tamoxifen
2.3.1.5 0.07
-
-
 Mus musculus alpha-zearalenol
2.3.1.5 0.1
-
 value above 0.1 mM Mus musculus pregnenolone
2.3.1.5 0.22
-
-
 Mus musculus zearalenone
2.3.1.5 0.29
-
-
 Mus musculus bisphenol A
2.3.1.5 0.37
-
-
 Mus musculus estrone
2.3.1.5 0.45
-
-
 Mus musculus beta-zearalenol
2.3.1.5 0.5
-
 value above 0.5 mM Mus musculus testosterone
2.3.1.5 0.5
-
 value above 0.5 mM Mus musculus androstenedione
2.3.1.5 0.5
-
 value above 0.5 mM Mus musculus 17-hydroxy-progesterone