EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.3.1.24 | additional information | BVR kinase activity is stimulated in the presence of double-stranded DNA fragments corresponding to HO-1 antioxidant and hypoxia response elements, as well as by haematin | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
1.3.1.24 | expressed in Escherichia coli and HeLa cells | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.3.1.24 | C281A/C292A/C293A | mutant is defective for protein-protein-dependent interaction and haematin binding | Homo sapiens |
1.3.1.24 | G17A | mutant is defective for ATP binding | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.3.1.24 | cytoplasm | - |
Homo sapiens | 5737 | - |
1.3.1.24 | nucleus | only kinase-competent BVR translocates to the nucleus | Homo sapiens | 5634 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.3.1.24 | Homo sapiens | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.1.24 | biliverdin + NAD(P)H + H+ | - |
Homo sapiens | bilirubin + NAD(P)+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.3.1.24 | BVR | BVR reduces biliverdin to the antioxidant bilirubin, functions as a kinase and as a transcription factor in the MAPK signalling cascade, as well as in the nuclear transport of haematin | Homo sapiens |
1.3.1.24 | BVR-A | isoform | Homo sapiens |
1.3.1.24 | BVR-B | isoform | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.3.1.24 | NAD(P)H | - |
Homo sapiens |