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Literature summary extracted from
- Hormonal regulation of the Menkes and Wilson copper-transporting ATPases in human placental Jeg-3 cells (2007), Biochem. J., 402, 241-250.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.2.2.9 | Insulin | increase of mRNA and protein levels of ATP7A | Homo sapiens |
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 7.2.2.9 | medicine | studies on copper deficiency during pregnancy, Menkes and Wilson disease | Homo sapiens |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 7.2.2.9 | membrane | - |
Homo sapiens | 16020 | - |
| 7.2.2.9 | membrane | basolateral membrane | Homo sapiens | 16020 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.2.2.9 | ATP + H2O + Cu2+/in | Homo sapiens | - |
ADP + phosphate + Cu2+/out | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.2.2.9 | Homo sapiens | P35670 | - |
- |
| 7.2.2.9 | Homo sapiens | Q04656 | ATP7A | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 7.2.2.9 | JEG-3 cell | - |
Homo sapiens | - |
| 7.2.2.9 | placenta | - |
Homo sapiens | - |
| 7.2.2.9 | syncytiotrophoblast | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 7.2.2.9 | additional information | - |
effect of hormone treatment on expression analyzed by Western blot, indirect immunocytochemistry and real-time PCR, copper transport and accumulation, insulin and oestrogen increase ATP7A mRNA and protein levels and alter the localization of ATP7A towards the basolateral membrane in a copper-independent manner, insulin and oestrogen increase the transport of copper across basolateral membrane, model of insulin and oestrogen effect on ATP7A and ATP7B in the placenta | Homo sapiens |
| 7.2.2.9 | additional information | - |
effect of hormone treatment on expression analyzed by Western blot, indirect immunocytochemistry and real-time PCR, copper transport and accumulation, levels of ATP7B decreased in response to insulin, protein shown to localize in a tight perinuclear region, corresponding decrease in copper efflux across the apical membrane, model of insulin and oestrogen effect on ATP7A and ATP7B in the human placenta | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.2.2.9 | ATP + H2O + Cu2+/in | - |
Homo sapiens | ADP + phosphate + Cu2+/out | - |
? | |
| 7.2.2.9 | ATP + H2O + Cu2+/in | differential regulation of ATP7A and ATP7B by the hormones insulin and oestrogen in human placental cells | Homo sapiens | ADP + phosphate + Cu2+/out | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 7.2.2.9 | ATP7A | - |
Homo sapiens |
| 7.2.2.9 | ATP7B | - |
Homo sapiens |
| 7.2.2.9 | Menkes copper-transporting ATPase | - |
Homo sapiens |
| 7.2.2.9 | MNK protein | - |
Homo sapiens |
| 7.2.2.9 | Wilson copper-transporting ATPase | - |
Homo sapiens |
| 7.2.2.9 | WND protein | - |
Homo sapiens |
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