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Literature summary extracted from

  • D'Angelo, M.A.; Sanquineti, S.; Reece, J.M.; Birnbaumer, L.; Torres, H.N.; Flawia, M.M.
    Identification, characterization and subcellular localization of TcPDE1, a novel cAMP-specific phosphodiesterase from Trypanosoma cruzi (2004), Biochem. J., 378, 63-72.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.53
-
 Trypanosoma cruzi

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.53 3-isobutyl-1-methylxanthine
-
 Trypanosoma cruzi
3.1.4.53 dipyridamole
-
 Trypanosoma cruzi
3.1.4.53 erythro-9-(2-hydroxy-3-nonyl)-adenine hydrochloride
-
 Trypanosoma cruzi
3.1.4.53 papaverine
-
 Trypanosoma cruzi
3.1.4.53 rolipram
-
 Trypanosoma cruzi
3.1.4.53 vinpocetine
-
 Trypanosoma cruzi

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.53 0.0073
-
 adenosine 3',5'-cyclic phosphate
-
 Trypanosoma cruzi

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.53 flagellum
-
 Trypanosoma cruzi
-
-
3.1.4.53 plasma membrane
-
 Trypanosoma cruzi 5886
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.53 Mg2+ activity was higher in the presence of Mn2+ than Mg2+ as cofactor Trypanosoma cruzi
3.1.4.53 Mn2+ activity was higher in the presence of Mn2+ than Mg2+ as cofactor Trypanosoma cruzi

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.53 Trypanosoma cruzi Q6XG56
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.53 adenosine 3',5'-cyclic phosphate + H2O
-
 Trypanosoma cruzi adenosine 5'-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.53 cAMP-specific phosphodiesterase
-
 Trypanosoma cruzi
3.1.4.53 TcPDE1
-
 Trypanosoma cruzi

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.4.53 0.017
-
-
 Trypanosoma cruzi dipyridamole
3.1.4.53 0.111
-
-
 Trypanosoma cruzi papaverine
3.1.4.53 0.134
-
-
 Trypanosoma cruzi vinpocetine
3.1.4.53 0.217
-
-
 Trypanosoma cruzi erythro-9-(2-hydroxy-3-nonyl)-adenine hydrochloride