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Literature summary extracted from

  • Iizuka, A.; Sengoku, K.; Iketani, M.; Nakamura, F.; Sato, Y.; Matsushita, M.; Nairn, A.C.; Takamatsu, K.; Goshima, Y.; Takei, K.
    Calcium-induced synergistic inhibition of a translational factor eEF2 in nerve growth cones (2007), Biochem. Biophys. Res. Commun., 353, 244-250.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.20 Calmodulin calcium-calmodulin-dependent enzyme Gallus gallus
2.7.11.20 additional information high potassium-evoked Ca2+ elevation enhances phosphorylation of eEF2 in growth cones, overview Gallus gallus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.20 additional information phosphorylation by p70-S6 kinase inhibits EF2K, Ca2+ decreases the phosphorylation of the enzyme Gallus gallus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.20 Ca2+ calcium-calmodulin-dependent enzyme, calcium also decreases the level of phosphorylated p70-S6 kinase, a kinase known to inhibit EF2K Gallus gallus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.20 ATP + [eukaryotic translation elongation factor 2] Gallus gallus eEF2 is involved in eEF2 in neurite outgrowth regulation mechanism, since phosphorylated eEF2 inhibits mRNA translation via inhibition of eEF2-ribosome binding, calcium elevation appears to inhibit mRNA translation in growth cones by a synergistic mechanism involving regulation of EF2K, S6K, and eEF2 itself, overview ADP + [eukaryotic translation elongation factor 2] phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.20 Gallus gallus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.20 phosphoprotein phosphorylation by p70-S6 kinase inhibits EF2K, Ca2+ decreases the phosphorylation of the enzyme Gallus gallus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.20 neuron DRG neurons Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.20 ATP + [eukaryotic translation elongation factor 2] phosphorylation at Thr56 Gallus gallus ADP + [eukaryotic translation elongation factor 2] phosphate
-
 ?
2.7.11.20 ATP + [eukaryotic translation elongation factor 2] eEF2 is involved in eEF2 in neurite outgrowth regulation mechanism, since phosphorylated eEF2 inhibits mRNA translation via inhibition of eEF2-ribosome binding, calcium elevation appears to inhibit mRNA translation in growth cones by a synergistic mechanism involving regulation of EF2K, S6K, and eEF2 itself, overview Gallus gallus ADP + [eukaryotic translation elongation factor 2] phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.20 eEF2 kinase
-
 Gallus gallus
2.7.11.20 EF2K
-
 Gallus gallus
2.7.11.20 More formerly CaMKIII Gallus gallus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.20 ATP
-
 Gallus gallus