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Literature summary extracted from

  • Gardner, C.; Robas, N.; Cawkill, D.; Fidock, M.
    Cloning and characterization of the human and mouse PDE7B, a novel cAMP-specific cyclic nucleotide phosphodiesterase (2000), Biochem. Biophys. Res. Commun., 272, 186-192.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.53 expression in Sf9 insect cells Mus musculus
3.1.4.53 expression in Sf9 insect cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.53 3-isobutyl-1-methyl-xanthine
-
 Mus musculus
3.1.4.53 3-isobutyl-1-methylxanthine
-
 Homo sapiens
3.1.4.53 dipyridamole
-
 Homo sapiens
3.1.4.53 dipyridamole
-
 Mus musculus
3.1.4.53 additional information zaprinast, rolipram, and milrinone do not significantly inhibit PDE7B Homo sapiens
3.1.4.53 additional information zaprinast, rolipram, and milrinone do not significantly inhibit PDE7B Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.53 0.0001
-
 adenosine 3',5'-cyclic phosphate
-
 Mus musculus
3.1.4.53 0.0002
-
 adenosine 3',5'-cyclic phosphate
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.53 Homo sapiens Q9NP56
-
-
3.1.4.53 Mus musculus Q9QXQ1
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.4.53
-
 Mus musculus
3.1.4.53
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.53 adenosine 3',5'-cyclic phosphate + H2O
-
 Mus musculus adenosine 5'-phosphate
-
 ?
3.1.4.53 adenosine 3',5'-cyclic phosphate + H2O
-
 Homo sapiens adenosine 5'-phosphate
-
 ?
3.1.4.53 additional information PDE7B does not hydrolyse cGMP Mus musculus ?
-
 ?
3.1.4.53 additional information PDE7B does not hydrolyse cGMP Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.53 PDE7B
-
 Mus musculus
3.1.4.53 PDE7B
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.4.53 0.00051
-
 pH 7.4, 30°C Mus musculus dipyridamole
3.1.4.53 0.00194
-
 pH 7.4, 30°C Homo sapiens dipyridamole
3.1.4.53 0.00381
-
 pH 7.4, 30°C Mus musculus 3-isobutyl-1-methyl-xanthine
3.1.4.53 0.00737
-
 pH 7.4, 30°C Homo sapiens 3-isobutyl-1-methylxanthine