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Literature summary extracted from
- Identification of human PDE7B, a cAMP-specific phosphodiesterase (2000), Biochem. Biophys. Res. Commun., 271, 575-583.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.1.4.53 | recombinant PDE7B expressed in transfected COS-7 cells | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.53 | 3-isobutyl-1-methylxanthine | - |
Homo sapiens |  |
| 3.1.4.53 | dipyridamole | - |
Homo sapiens | |
| 3.1.4.53 | E4021 | - |
Homo sapiens | |
| 3.1.4.53 | additional information | EHNA, milrinone, rolipram, and zaprinast, which are PDE2, PDE3, and PDE4 inhibitors, respectively, do not inhibit the PDE7B activity up to concentrations of 0.100 mM | Homo sapiens | |
| 3.1.4.53 | SCH51866 | - |
Homo sapiens | |
| 3.1.4.53 | vinpocetine | - |
Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.1.4.53 | 0.00013 | - |
adenosine 3',5'-cyclic phosphate | PDE7B expressed in transfected COS-7 cells | Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.4.53 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.4.53 | caudate nucleus | - |
Homo sapiens | - |
| 3.1.4.53 | caudate putamen | - |
Homo sapiens | - |
| 3.1.4.53 | heart | - |
Homo sapiens | - |
| 3.1.4.53 | occipital pole | - |
Homo sapiens | - |
| 3.1.4.53 | pancreas | - |
Homo sapiens | - |
| 3.1.4.53 | skeletal muscle | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.53 | adenosine 3',5'-cyclic phosphate + H2O | - |
Homo sapiens | adenosine 5'-phosphate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.4.53 | PDE7B | - |
Homo sapiens |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.1.4.53 | 0.0011 | - |
- |
Homo sapiens | dipyridamole | |
| 3.1.4.53 | 0.0015 | - |
PDE7B expressed in transfected COS-7 cells | Homo sapiens | SCH51866 | |
| 3.1.4.53 | 0.0099 | - |
- |
Homo sapiens | 3-isobutyl-1-methylxanthine | |
| 3.1.4.53 | 0.015 | - |
- |
Homo sapiens | E4021 | |
| 3.1.4.53 | 0.059 | - |
- |
Homo sapiens | vinpocetine | |
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Release 2023.1 (January 2023)
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