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Literature summary extracted from

  • Landmesser, U.; Spiekermann, S.; Preuss, C.; Sorrentino, S.; Fischer, D.; Manes, C.; Mueller, M.; Drexler, H.
    Angiotensin II induces endothelial xanthine oxidase activation: role for endothelial dysfunction in patients with coronary disease (2007), Arterioscler. Thromb. Vasc. Biol., 27, 943-948.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.17.3.2 angiotensin II Ang II substantially increases endothelial enzyme protein levels and enzyme-dependent superoxide production in cultured endothelial cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.3.2 allopurinol enzyme inhibition with allopurinol does not improve endothelium-dependent vasodilation before Homo sapiens
1.17.3.2 losartan in patients with coronary disease, losartan therapy reduces endothelium-bound xanthine oxidase activity likely contributing to improved endothelial function, enzyme inhibition with losartan does not improve endothelium-dependent vasodilation before Homo sapiens
1.17.3.2 oxypurinol enzyme inhibition with oxypurinol improves endothelium-dependent vasodilation before Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.3.2 additional information Homo sapiens the enzyme and its superoxide producing activity are involved in endothelial dysfunction in atherosclerosis, overview ?
-
 ?
1.17.3.2 xanthine + H2O + O2 Homo sapiens
-
 urate + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.3.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.3.2 endothelium
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.3.2 additional information the enzyme and its superoxide producing activity are involved in endothelial dysfunction in atherosclerosis, overview Homo sapiens ?
-
 ?
1.17.3.2 xanthine + H2O + O2
-
 Homo sapiens urate + H2O2
-
 ?