EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.14.14.18 | additional information | a clinically relevant polymorphism within the HO-1 promoter critically influences its transcriptional activation by both PPAR isoforms, overview | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.14.18 | tin protoporphyrin | SnPP, specific HO-1 inhibition abrogating the inhibition of COX-2 expression by Wy-14,643 | Homo sapiens | |
1.14.14.18 | zinc protoporphyrin | dose-dependently increases SMC proliferation, induced by either platelet-derived growth factor or 15% fetal bovine serum | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.18 | heme + AH2 + O2 | Homo sapiens | HO-1 shows vasculoprotective and anti-inflammatory activity, it is ptionally regulated by peroxisome proliferator-activated receptors PPARalpha and PPARgamma in vascular cells, inhibition of HO-1 enzymatic activity reverses PPAR ligand-mediated inhibition of cell proliferation and expression of cyclooxygenase-2 in vascular smooth muscle cells, overview | biliverdin + Fe2+ + CO + A + H2O | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.14.18 | Homo sapiens | P09601 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.14.18 | smooth muscle cell | - |
Homo sapiens | - |
1.14.14.18 | vascular endothelial cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.18 | heme + AH2 + O2 | - |
Homo sapiens | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
1.14.14.18 | heme + AH2 + O2 | HO-1 shows vasculoprotective and anti-inflammatory activity, it is ptionally regulated by peroxisome proliferator-activated receptors PPARalpha and PPARgamma in vascular cells, inhibition of HO-1 enzymatic activity reverses PPAR ligand-mediated inhibition of cell proliferation and expression of cyclooxygenase-2 in vascular smooth muscle cells, overview | Homo sapiens | biliverdin + Fe2+ + CO + A + H2O | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.14.18 | heme oxygenase-1 | - |
Homo sapiens |
1.14.14.18 | HO-1 | - |
Homo sapiens |