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Literature summary extracted from

  • Jung, K.; Kim, S.; Lee, K.; Kim, C.; Chung, I.
    Cytotoxic effect of a replication-incompetent adenoviral vector with cytosine deaminase gene driven by L-plastin promoter in hepatocellular carcinoma cells (2007), Arch. Pharm. Res., 30, 770-777.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.4.1 expression of the enzyme from a replication-incompetent vector, comprising the cytosine deaminase gene and the L-plastin promoter, in human hepatocellular carcinoma cell lines HepG2, Chang Liver, Huh-7 and SK-Hep-1, expression analysis in the different cell lines, overview Escherichia coli

Protein Variants

EC Number Protein Variants Comment Organism
3.5.4.1 additional information construction of a replication-incompetent vector, i.e. AdLPCD vector, comprising the cytosine deaminase gene and the L-plastin promoter, which regulates the expression of transgenes Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.1 5-fluorocytosine + H2O Escherichia coli recombinant enzyme in transfected cells, cytotoxic effects of the enzyme expressed form the AdLPCD vector, overview 5-fluorouracil + NH3
-
 ?
3.5.4.1 cytosine + H2O Escherichia coli
-
 uracil + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.1 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.1 5-fluorocytosine + H2O
-
 Escherichia coli 5-fluorouracil + NH3
-
 ?
3.5.4.1 5-fluorocytosine + H2O recombinant enzyme in transfected cells, cytotoxic effects of the enzyme expressed form the AdLPCD vector, overview Escherichia coli 5-fluorouracil + NH3
-
 ?
3.5.4.1 cytosine + H2O
-
 Escherichia coli uracil + NH3
-
 ?