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Literature summary extracted from

  • Choi, S.I.; Jeong, C.S.; Cho, S.Y.; Lee, Y.S.
    Mechanism of apoptosis induced by apigenin in HepG2 human hepatoma cells: involvement of reactive oxygen species generated by NADPH oxidase (2007), Arch. Pharm. Res., 30, 1328-1335.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.6.3.1 apigenin apigenin reduces cell viability, and induces apoptotic cell death in a dose-dependent manner. In addition, it evokes a dose-related elevation of intracellular reactive oxygen species level. Treatment with various inhibitors of the NADPH oxidase significantly blunts both the generation of reactive oxygen species and induction of apoptosis induced by apigenin Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.6.3.1 apocynin significantly blunts both the generation of reactive oxygen species and induction of apoptosis induced by apigenin Homo sapiens
1.6.3.1 diphenylene iodonium significantly blunts both the generation of reactive oxygen species and induction of apoptosis induced by apigenin Homo sapiens
1.6.3.1 neopterin significantly blunts both the generation of reactive oxygen species and induction of apoptosis induced by apigenin Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.6.3.1 Homo sapiens
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-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.3.1 Hep-G2 cell
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Homo sapiens
-