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Literature summary extracted from

  • Xiao, L.; Matsubayashi, K.; Miwa, N.
    Inhibitory effect of the water-soluble polymer-wrapped derivative of fullerene on UVA-induced melanogenesis via downregulation of tyrosinase expression in human melanocytes and skin tissues (2007), Arch. Dermatol. Res., 299, 245-257.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.18.1 additional information UVA induced oxidative stress is considered to promote melanogenesis and serious skin damage. UVA-induced reactive oxygen species (ROS), ROS causes tyrosinase gene transcription Homo sapiens

Application

EC Number Application Comment Organism
1.14.18.1 pharmacology results indicate that the polyvinylpyrrolidone (PVP)-wrapped fullerene derivative (Radical Sponge) could be expected for its wide-ranged application as a whitening cosmetic material Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 arbutin as compared with two major effective cosmetic additives, arbutin and L-ascorbic acid, the polyvinylpyrrolidone (PVP)-wrapped fullerene derivative (Radical Sponge) shows the more marked depigmenting effect in human melanocytes or melanoma cells Homo sapiens
1.14.18.1 L-ascorbic acid as compared with two major effective cosmetic additives, arbutin and L-ascorbic acid, the polyvinylpyrrolidone (PVP)-wrapped fullerene derivative (Radical Sponge) shows the more marked depigmenting effect in human melanocytes or melanoma cells Homo sapiens
1.14.18.1 polyvinylpyrrolidone (PVP)-wrapped fullerene derivative inhibitory effect of the water-soluble polymer-wrapped derivative of fullerene, named Radical Sponge. As compared with two major effective cosmetic additives, arbutin and L-ascorbic acid, the polyvinylpyrrolidone (PVP)-wrapped fullerene derivative (Radical Sponge) shows the more marked depigmenting effect in human melanocytes or melanoma cells Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.18.1 HMV-II cell human melanoma cell Homo sapiens
-
1.14.18.1 NHEM cell human normal epidermis melanocytes Homo sapiens
-
1.14.18.1 skin human fresh skin tissues from volunteers Homo sapiens
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Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 tyrosinase
-
Homo sapiens