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Literature summary extracted from

  • Schnorr, O.; Brossette, T.; Momma, T.Y.; Kleinbongard, P.; Keen, C.L.; Schroeter, H.; Sies, H.
    Cocoa flavanols lower vascular arginase activity in human endothelial cells in vitro and in erythrocytes in vivo (2008), Arch. Biochem. Biophys., 476, 211-215.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.3.1 (-)-epicatechin (-)-epicatechin leads to a decreased arginase-2 mRNA expression after 24 h of incubation, in contrast a weak basal arginase-1 mRNA expression is not affected Homo sapiens
3.5.3.1 (-)-epicatechin (-)-epicatechin leads to a decreased arginase-2 mRNA expression after 24 h of incubation, in contrast a weak basal arginase-1 mRNA expression is not affected Rattus norvegicus
3.5.3.1 flavanol-rich cocoa cocoa flavanols lower arginase-2 mRNA expression and activity Homo sapiens
3.5.3.1 flavanol-rich cocoa cocoa flavanols lower arginase-2 mRNA expression and activity Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.3.1 L-arginine + H2O Homo sapiens arginase competes with nitric oxide synthases for L-arginine as the common substrate L-ornithine + urea
-
 ?
3.5.3.1 L-arginine + H2O Rattus norvegicus arginase competes with nitric oxide synthases for L-arginine as the common substrate L-ornithine + urea
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.3.1 Homo sapiens
-
-
-
3.5.3.1 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.3.1 endothelial cell
-
 Homo sapiens
-
3.5.3.1 erythrocyte
-
 Homo sapiens
-
3.5.3.1 HUVEC cell
-
 Homo sapiens
-
3.5.3.1 kidney
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.3.1 L-arginine + H2O arginase competes with nitric oxide synthases for L-arginine as the common substrate Homo sapiens L-ornithine + urea
-
 ?
3.5.3.1 L-arginine + H2O arginase competes with nitric oxide synthases for L-arginine as the common substrate Rattus norvegicus L-ornithine + urea
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.3.1 arginase-2
-
 Homo sapiens
3.5.3.1 arginase-2
-
 Rattus norvegicus