Literature summary extracted from

Crosley, L.K.; Meplan, C.; Nicol, F.; Rundloef, A.K.; Arner, E.S.; Hesketh, J.E.; Arthur, J.R.
Differential regulation of expression of cytosolic and mitochondrial thioredoxin reductase in rat liver and kidney (2007), Arch. Biochem. Biophys., 459, 178-188.

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining

Metals/Ions

EC Number	Metals/Ions	Comment	Organism	Structure
1.8.1.9	selenium	selenoprotein. TrxR1 is more sensitive to Se depletion than TrxR2, greater changes in liver than kidney. There is a prioritisation of TrxR2 over TrxR1 during Se deficiency such that TrxR1 expression is more sensitive to Se supply than TrxR2 but this sensitivity of TrxR1 is not fully accounted for by TrxR1 5' or 3'-untranslated region sequences when assessed using luciferase reporter constructs	Rattus norvegicus

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.8.1.9	Rattus norvegicus	O89049	male Hooded Lister rats of the Rowett strain	-
1.8.1.9	Rattus norvegicus Rowett	O89049	male Hooded Lister rats of the Rowett strain	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.8.1.9	kidney	-	Rattus norvegicus	-
1.8.1.9	liver	-	Rattus norvegicus	-

Synonyms

EC Number	Synonyms	Comment	Organism
1.8.1.9	thioredoxin reductase	-	Rattus norvegicus
1.8.1.9	TrxR1	-	Rattus norvegicus

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Release 2023.1 (January 2023)