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Literature summary extracted from
- The action of Pdcd4 may be cell type specific: evidence that reduction of dUTPase levels might contribute to its tumor suppressor activity in Bon-1 cells (2008), Apoptosis, 13, 157-164.
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 3.6.1.23 | additional information | overexpression of programmed cell death protein 4, Pdcd4, in a human endocrine pancreatic cell line Bon-1 decreases levels of dUTPase, but does not in colon carcinoma cell line HCT116, treatment of a human breast adenocarcinoma cell line MCF-7, with 5-fluorouracil results in regulated expression of Pdcd4 and dUTPase, overview | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.6.1.23 | additional information | programmed cell death protein 4 downregulates dUTPase in certain cell types, overview | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.6.1.23 | dUTP + H2O | Homo sapiens | - |
dUMP + diphosphate | - |
? |  |
| 3.6.1.23 | additional information | Homo sapiens | overexpression of dUTPase is associated with resistance to chemotherapeutic agents targeting thymidilate biosynthesis | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.6.1.23 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.6.1.23 | BON-1 cell | an endocrine pancreatic cell line | Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.6.1.23 | dUTP + H2O | - |
Homo sapiens | dUMP + diphosphate | - |
? | |
| 3.6.1.23 | additional information | overexpression of dUTPase is associated with resistance to chemotherapeutic agents targeting thymidilate biosynthesis | Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.6.1.23 | dUTPase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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