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Literature summary extracted from

  • Hung, H.C.; Lin, C.Y.; Liao, Y.F.; Hsu, P.C.; Tsay, G.J.; Liu, G.Y.
    The functional haplotype of peptidylarginine deiminase IV (S55G, A82V and A112G) associated with susceptibility to rheumatoid arthritis dominates apoptosis of acute T leukemia Jurkat cells (2007), Apoptosis, 12, 475-487.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.5.3.15 additional information ionomycin induces PADI4 expression Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.3.15 gene padi4, DNA and amino acid sequence determination and analysis of wild-type and mutant enzymes Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.5.3.15 A82V/A112G naturally occuring single-nucleotide polymorphisms and site-directed mutagenesis, the SNP-PADI4 mutant haplotype shows a higher risk of rheumatoid arthritis due to correlation with the RA gene, because the mutant shows increased activity, compared to the wild-type PADI4, which promotes the autoimmune disease and apoptosis, overview Homo sapiens
3.5.3.15 S55G/A112G naturally occuring single-nucleotide polymorphisms and site-directed mutagenesis, the SNP-PADI4 mutant haplotype shows a higher risk of rheumatoid arthritis due to correlation with the RA gene, because the mutant shows increased activity, compared to the wild-type PADI4, which promotes the autoimmune disease and apoptosis, overview Homo sapiens
3.5.3.15 S55G/A82V naturally occuring single-nucleotide polymorphisms and site-directed mutagenesis, the SNP-PADI4 mutant haplotype shows reduced activity compared to the wild-type PADI4 Homo sapiens
3.5.3.15 S55G/A82V/A112G naturally occuring single-nucleotide polymorphisms and site-directed mutagenesis, the SNP-PADI4 mutant haplotype shows a higher risk of rheumatoid arthritis due to correlation with the RA gene, because the mutant shows increased activity, compared to the wild-type PADI4, which promotes the autoimmune disease and apoptosis, overview Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.3.15 Ca2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.3.15 protein-L-arginine + H2O Homo sapiens posttranslational convertion, PADI4 plays an essential role in immune cell differentiation and apoptosis, ionomycin-inducible PADI4-decreased cell viability and PADI4-enhanced apoptosis, overview protein-L-citrulline + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.3.15 Homo sapiens
-
 gene padi4, isozyme PADI4
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.3.15 JURKAT cell T-cell leukemia cell line with tetracycline resistance Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.3.15 protein-L-arginine + H2O
-
 Homo sapiens protein-L-citrulline + NH3
-
 ?
3.5.3.15 protein-L-arginine + H2O posttranslational convertion, PADI4 plays an essential role in immune cell differentiation and apoptosis, ionomycin-inducible PADI4-decreased cell viability and PADI4-enhanced apoptosis, overview Homo sapiens protein-L-citrulline + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.3.15 PADI4
-
 Homo sapiens
3.5.3.15 peptidylarginine deiminase IV
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.5.3.15 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.3.15 7.5
-
 assay at Homo sapiens