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Literature summary extracted from

  • Joung, E.J.; Li, M.H.; Lee, H.G.; Somparn, N.; Jung, Y.S.; Na, H.K.; Kim, S.H.; Cha, Y.N.; Surh, Y.J.
    Capsaicin induces heme oxygenase-1 expression in HepG2 cells via activation of PI3K-Nrf2 signaling: NAD(P)H:quinone oxidoreductase as a potential target (2007), Antioxid. Redox Signal., 9, 2087-2098.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.14.18 additional information capsaicin, i.e. trans-8-methyl-N-vanillyl-6-nonenamide, induces heme oxygenase-1 expression in Hep-G2 cells via activation of PI3K-Nrf2 signaling Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.6.5.2 capsaicin activity is decreased after the treatment with capsaicin or dicoumarol. Quinone metabolites or other reactive forms of capsaicin may bind covalently to NQO1 and thereby inhibit its activity, leading to production of reactive oxygen species; suppresses NQO1 expression and activity. Quinone metabolites or other reactive forms of capsaicin may bind covalently to NQO1 and thereby inhibit its activity, leading to production of reactive oxygen species Homo sapiens
1.6.5.2 dicoumarol
-
 Homo sapiens
1.6.5.2 dicumarol
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.18 heme + AH2 + O2 Homo sapiens
-
 biliverdin + Fe2+ + CO + A + H2O
-
 ?
1.14.14.18 additional information Homo sapiens capsaicin induces heme oxygenase-1 expression in Hep-G2 cells via activation of PI3K-Nrf2 signaling, and capsaicin protects against SIN-1-induced cytotoxicity, which is abolished by HO-1 inhibition ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.6.5.2 Homo sapiens
-
-
-
1.14.14.18 Homo sapiens P09601
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.5.2 Hep-G2 cell
-
 Homo sapiens
-
1.14.14.18 Hep-G2 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.18 heme + AH2 + O2
-
 Homo sapiens biliverdin + Fe2+ + CO + A + H2O
-
 ?
1.14.14.18 additional information capsaicin induces heme oxygenase-1 expression in Hep-G2 cells via activation of PI3K-Nrf2 signaling, and capsaicin protects against SIN-1-induced cytotoxicity, which is abolished by HO-1 inhibition Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.6.5.2 NAD(P)H:quinone oxidoreductase
-
 Homo sapiens
1.6.5.2 NQO1
-
 Homo sapiens
1.14.14.18 heme oxygenase-1
-
 Homo sapiens
1.14.14.18 HO-1
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.14.18 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.14.18 7.4
-
 assay at Homo sapiens