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Literature summary extracted from

  • Kedar, G.C.; Brown-Driver, V.; Reyes, D.R.; Hilgers, M.T.; Stidham, M.A.; Shaw, K.J.; Finn, J.; Haselbeck, R.J.
    Comparison of the essential cellular functions of the two murA genes of Bacillus anthracis (2008), Antimicrob. Agents Chemother., 52, 2009-2013.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.5.1.7 additional information antisense-based modulation of murA1 gene expression, which encodes UDP-N-acetylglucosamine enolpyruvyl transferase, hypersensitizes cells to the MurA-specific antibiotic fosfomycin despite the normally high resistance of Bacillus anthracis to this drug Bacillus anthracis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.7 fosfomycin
-
Bacillus anthracis

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.7 Bacillus anthracis
-
isoforms MurA1, murA2
-

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.5.1.7 additional information
-
in wild-type background, IC50 of fosfomycin is 2,048 microg/ml. In a strain with antisense-based expression attenuation of the MurA1 gene encoding UDP-N-acetylglucosamine enolpyruvyl transferase, IC50 value is 126 microg/ml. Prsence of xylose further decreases the IC50 value to 18 microg/ml Bacillus anthracis additional information