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Literature summary extracted from

  • Matsumoto, J.; Sakamoto, K.; Shinjyo, N.; Kido, Y.; Yamamoto, N.; Yagi, K.; Miyoshi, H.; Nonaka, N.; Katakura, K.; Kita, K.; Oku, Y.
    Anaerobic NADH-fumarate reductase system is predominant in the respiratory chain of Echinococcus multilocularis, providing a novel target for the chemotherapy of alveolar echinococcosis (2008), Antimicrob. Agents Chemother., 52, 164-170.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.6 1-[[2-(4-tert-butylphenyl)ethyl]amino]phthalazin-5-ol
-
 Echinococcus multilocularis
1.3.1.6 N-(4-[[2-(4-tert-butylphenyl)ethyl]amino]phthalazin-6-yl)prop-2-enamide
-
 Echinococcus multilocularis
1.3.1.6 N-[2-(4-tert-butylphenyl)ethyl]-5-(1-methylethoxy)phthalazin-1-amine
-
 Echinococcus multilocularis
1.3.1.6 N-[2-(4-tert-butylphenyl)ethyl]-5-methoxyphthalazin-1-amine
-
 Echinococcus multilocularis
1.3.1.6 N-[2-(4-tert-butylphenyl)ethyl]phthalazin-1-amine quinazoline Echinococcus multilocularis
1.3.1.6 N1-[2-(4-tert-butylphenyl)ethyl]phthalazine-1,6-diamine
-
 Echinococcus multilocularis
1.3.1.6 N1-[2-(4-tert-butylphenyl)ethyl]phthalazine-1,7-diamine
-
 Echinococcus multilocularis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.6 mitochondrion
-
 Echinococcus multilocularis 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.6 Echinococcus multilocularis
-
-
-
1.3.1.6 Echinococcus multilocularis Nemuro
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.6 protoscolex
-
 Echinococcus multilocularis
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.3.1.6 0.045
-
 in 30 mM potassium phosphate (pH 7.4) and 1 mM MgCl, at 25°C Echinococcus multilocularis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.6 fumarate + NADH + H+
-
 Echinococcus multilocularis succinate + NAD+
-
 ?
1.3.1.6 fumarate + NADH + H+
-
 Echinococcus multilocularis Nemuro succinate + NAD+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.6 NADH
-
 Echinococcus multilocularis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.3.1.6 0.0021
-
 in 30 mM potassium phosphate (pH 7.4) and 1 mM MgCl2, at 25°C Echinococcus multilocularis N1-[2-(4-tert-butylphenyl)ethyl]phthalazine-1,7-diamine
1.3.1.6 0.0023
-
 in 30 mM potassium phosphate (pH 7.4) and 1 mM MgCl2, at 25°C Echinococcus multilocularis N-[2-(4-tert-butylphenyl)ethyl]phthalazin-1-amine
1.3.1.6 0.016
-
 in 30 mM potassium phosphate (pH 7.4) and 1 mM MgCl2, at 25°C Echinococcus multilocularis N-(4-[[2-(4-tert-butylphenyl)ethyl]amino]phthalazin-6-yl)prop-2-enamide
1.3.1.6 0.048
-
 in 30 mM potassium phosphate (pH 7.4) and 1 mM MgCl2, at 25°C Echinococcus multilocularis N-[2-(4-tert-butylphenyl)ethyl]-5-methoxyphthalazin-1-amine
1.3.1.6 0.062
-
 in 30 mM potassium phosphate (pH 7.4) and 1 mM MgCl2, at 25°C Echinococcus multilocularis N1-[2-(4-tert-butylphenyl)ethyl]phthalazine-1,6-diamine
1.3.1.6 0.071
-
 in 30 mM potassium phosphate (pH 7.4) and 1 mM MgCl2, at 25°C Echinococcus multilocularis 1-[[2-(4-tert-butylphenyl)ethyl]amino]phthalazin-5-ol
1.3.1.6 0.91
-
 in 30 mM potassium phosphate (pH 7.4) and 1 mM MgCl2, at 25°C Echinococcus multilocularis N-[2-(4-tert-butylphenyl)ethyl]-5-(1-methylethoxy)phthalazin-1-amine
1.3.1.6 4.1
-
 in 30 mM potassium phosphate (pH 7.4) and 1 mM MgCl2, at 25°C Echinococcus multilocularis N-[2-(4-tert-butylphenyl)ethyl]-5-methoxyphthalazin-1-amine