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Literature summary extracted from

  • Avolio, T.M.; Lee, Y.; Feng, N.; Xiong, K.; Jin, H.; Wang, M.; Vassilakos, A.; Wright, J.; Young, A.
    RNA interference targeting the R2 subunit of ribonucleotide reductase inhibits growth of tumor cells in vitro and in vivo (2007), Anticancer Drugs, 18, 377-388.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.17.4.1 additional information expression of subunit R2 siRNA 1284, targeting the AA(N19) sequence motif, inhibits R2 expression and active enzyme complex formation in different cell lines, it also inhibits cell growth and proloferation in vitro by blocking in the S-phase of the cell cycle, overview Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.17.4.1 78000
-
 2 * 160000, subunit R1, + 2 * 78000, subunit R2, the catalytic active enzyme forms a dimer of homodimers Homo sapiens
1.17.4.1 160000
-
 2 * 160000, subunit R1, + 2 * 78000, subunit R2, the catalytic active enzyme forms a dimer of homodimers Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.4.1 ribonucleoside 5'-diphosphate + thioredoxin Homo sapiens the essential enzyme catalyzes the rate-limiting step in dNTP production for DNA synthesis 2'-deoxyribonuleoside 5'-diphosphate + thioredoxin disulfide + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.4.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.4.1 A-2058 cell
-
 Homo sapiens
-
1.17.4.1 A-498 cell
-
 Homo sapiens
-
1.17.4.1 HT-29 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.4.1 ribonucleoside 5'-diphosphate + thioredoxin
-
 Homo sapiens 2'-deoxyribonuleoside 5'-diphosphate + thioredoxin disulfide + H2O
-
 ?
1.17.4.1 ribonucleoside 5'-diphosphate + thioredoxin the essential enzyme catalyzes the rate-limiting step in dNTP production for DNA synthesis Homo sapiens 2'-deoxyribonuleoside 5'-diphosphate + thioredoxin disulfide + H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
1.17.4.1 tetramer 2 * 160000, subunit R1, + 2 * 78000, subunit R2, the catalytic active enzyme forms a dimer of homodimers Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.17.4.1 ribonucleotide reductase
-
 Homo sapiens
1.17.4.1 RNR
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.17.4.1 thioredoxin
-
 Homo sapiens