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Literature summary extracted from

  • Harwood, J.L.
    Temperature stress: reacting and adapting: lessons from poikilotherms (2007), Ann. N. Y. Acad. Sci., 1113, 52-57.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.19.39 additional information the enzyme is independently induced by oxygen, and temperature, while chilling alone is not sufficient to raise the enzyme activity. Chilling and lowered temperature cause an increase in desaturase activity, increased membrane unsaturation and subsequently fluidity, followed by phagocytosis, overview Acanthamoeba castellanii

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.19.39 expression in Saccharomyces cerevisiae Acanthamoeba castellanii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.39 additional information Acanthamoeba castellanii key enzyme in adaptation to low temperature, sequential changes in fatty acid composition on lowering environmental temperature, overview ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.39 Acanthamoeba castellanii
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-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.19.39 cell culture cell growth between 4°C and 32°C Acanthamoeba castellanii
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.39 additional information key enzyme in adaptation to low temperature, sequential changes in fatty acid composition on lowering environmental temperature, overview Acanthamoeba castellanii ?
-
 ?
1.14.19.39 additional information substrate specificity, the recombinant enzyme catalyzes also the DELTA15-desaturation of fatty acids, and is capable of producing very unusual n-1 polyunsaturated products, overview Acanthamoeba castellanii ?
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 ?
1.14.19.39 oleate + AH2 + O2 oxygenation at the sn-2 position Acanthamoeba castellanii linoleate + A + 2 H2O
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 ?
1.14.19.39 palmitoleoate + AH2 + O2 via intermediate DELTA9,12 hexadecadienoate Acanthamoeba castellanii 9,12,15-hexadecatrienoate + A + H2O the product is n-1 polyunsaturated ?
1.14.19.39 phosphatidylcholine + AH2 + O2
-
 Acanthamoeba castellanii ?
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 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.39 DELTA12-fatty acid desaturase
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 Acanthamoeba castellanii