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Literature summary extracted from

  • Hoertner, S.R.; Ritschel, T.; Stengl, B.; Kramer, C.; Schweizer, W.B.; Wagner, B.; Kansy, M.; Klebe, G.; Diederich, F.
    Potent inhibitors of tRNA-guanine transglycosylase, an enzyme linked to the pathogenicity of the Shigella bacterium: charge-assisted hydrogen bonding (2007), Angew. Chem., 46, 8266-8269.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.29 2,6-diamino-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
 Shigella flexneri
2.4.2.29 6-amino-2-(benzylamino)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
 Shigella flexneri
2.4.2.29 6-amino-2-(methylamino)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
 Shigella flexneri
2.4.2.29 6-amino-2-methyl-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
 Shigella flexneri
2.4.2.29 6-amino-2-[(1,3-benzodioxol-5-ylmethyl)amino]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
 Shigella flexneri
2.4.2.29 6-amino-2-[(2-morpholin-4-ylethyl)amino]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
 Shigella flexneri
2.4.2.29 6-amino-2-[(2-phenylethyl)amino]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
 Shigella flexneri
2.4.2.29 6-amino-2-[(4-morpholin-4-ylbenzyl)amino]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
 Shigella flexneri
2.4.2.29 6-amino-2-[(naphthalen-1-ylmethyl)amino]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
 Shigella flexneri
2.4.2.29 6-amino-2-[(quinolin-4-ylmethyl)amino]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
 Shigella flexneri
2.4.2.29 6-amino-2-[(thiophen-2-ylmethyl)amino]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
 Shigella flexneri
2.4.2.29 6-aminoimidazol[4,5-g]quinazolin-8(7H)-one mixed competitive-uncompetitive inhibition with respect to tRNA binding Shigella flexneri

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.29 Shigella flexneri Q54177
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.29 guanine34 in tRNA + 7-aminomethyl-7-carbaguanine
-
 Shigella flexneri 7-aminomethyl-7-carbaguanine34 in tRNA + guanine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.29 TGT
-
 Shigella flexneri

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.2.29 0.000006
-
 6-amino-2-[(2-morpholin-4-ylethyl)amino]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
 Shigella flexneri
2.4.2.29 0.00001
-
 6-amino-2-[(2-phenylethyl)amino]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
 Shigella flexneri
2.4.2.29 0.000027
-
 6-amino-2-[(quinolin-4-ylmethyl)amino]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
 Shigella flexneri
2.4.2.29 0.000035
-
 6-amino-2-[(thiophen-2-ylmethyl)amino]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
 Shigella flexneri
2.4.2.29 0.000035
-
 6-amino-2-[(1,3-benzodioxol-5-ylmethyl)amino]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
 Shigella flexneri
2.4.2.29 0.00004
-
 6-amino-2-[(4-morpholin-4-ylbenzyl)amino]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
 Shigella flexneri
2.4.2.29 0.000055
-
 6-amino-2-[(naphthalen-1-ylmethyl)amino]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
 Shigella flexneri
2.4.2.29 0.000058
-
 6-amino-2-(methylamino)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
 Shigella flexneri
2.4.2.29 0.00007
-
 6-amino-2-(benzylamino)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
 Shigella flexneri
2.4.2.29 0.000077
-
 2,6-diamino-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
 Shigella flexneri
2.4.2.29 0.0016
-
 6-amino-2-methyl-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
-
 Shigella flexneri
2.4.2.29 0.0041
-
 6-aminoimidazol[4,5-g]quinazolin-8(7H)-one
-
 Shigella flexneri