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Literature summary extracted from

  • Mizuno, Y.; Isotani, E.; Huang, J.; Ding, H.; Stull, J.T.; Kamm, K.E.
    Myosin light chain kinase activation and calcium sensitization in smooth muscle in vivo (2008), Am. J. Physiol. Cell Physiol., 295, C358-C364.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.18 Calmodulin the enzyme is dependent on Ca2+ and calmodulin Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.53 expressed in Mus musculus Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.18 Carbachol increases Ca2+ concentration, MLCK activation and regulatory light chain phosphorylation Mus musculus
2.7.11.18 KCl increases Ca2+ concentration, MLCK activation and regulatory light chain phosphorylation Mus musculus
3.1.3.53 additional information MLCP inhibition may occur through RhoA/Rhokinase and/or protein kinase C with phosphorylation of myosin phosphatase targeting subunit-1 and protein kinase C-potentiated phosphatase inhibitor (CPI-17), respectively Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.18 Ca2+ the enzyme is dependent on Ca2+ and calmodulin, the intracellular Ca2+ concentration has regulatory effect, overview Mus musculus
2.7.11.18 Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.18 ATP + myosin regulatory light chain Mus musculus
-
 ADP + phosphorylated myosin regulatory light chain
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.18 Mus musculus
-
-
-
3.1.3.53 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.18 bladder
-
 Mus musculus
-
2.7.11.18 smooth muscle from bladder Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.11.18 additional information
-
-
 Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.18 ATP + myosin regulatory light chain
-
 Mus musculus ADP + phosphorylated myosin regulatory light chain
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.18 MLCK
-
 Mus musculus
2.7.11.18 myosin light chain kinase
-
 Mus musculus
3.1.3.53 MLCP
-
 Homo sapiens
3.1.3.53 myosin light chain phosphatase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.18 ATP
-
 Mus musculus