Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Sundaram, U.; Wisel, S.; Coon, S.
    Neutral Na-amino acid cotransport is differentially regulated by glucocorticoids in the normal and chronically inflamed rabbit small intestine (2007), Am. J. Physiol., 292, G467-G474.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.4.2.2 methylprednisolone stimulates Na-alanine cotransport in the normal intestine, mechanism of stimulation is secondary to an increase in cotransporter numbers without an alteration in the affinity for the amino acid. Treatment with MP reverses the reduction in Na-alanine cotransport in villus cells from the chronically inflamed intestine, secondary to restoration in the affinity for the amino acid without a change in the Vmax, overview Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.4.2.2 ATP + H2O + alanine/out Oryctolagus cuniculus neutral Na-amino acid cotransport, e.g. Na-alanine cotransport, is differentially regulated by glucocorticoids in the normal and chronically inflamed rabbit small intestine, treatment with MP reverses the reduction in Na-alanine cotransport in villus cells from the chronically inflamed intestine, secondary to restoration in the affinity for the amino acid without a change in the Vmax, overview ADP + phosphate + alanine/in
-
 ?
7.4.2.2 ATP + H2O + nonpolar amino acid/out Oryctolagus cuniculus neutral Na-amino acid cotransport is differentially regulated by glucocorticoids in the normal and chronically inflamed rabbit small intestine, overview ADP + phosphate + nonpolar amino acid/in
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.4.2.2 Oryctolagus cuniculus
-
 New Zealand White male rabbits
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.4.2.2 small intestine from normal and chronically inflamed rabbits Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.4.2.2 ATP + H2O + alanine/out
-
 Oryctolagus cuniculus ADP + phosphate + alanine/in
-
 ?
7.4.2.2 ATP + H2O + alanine/out neutral Na-amino acid cotransport, e.g. Na-alanine cotransport, is differentially regulated by glucocorticoids in the normal and chronically inflamed rabbit small intestine, treatment with MP reverses the reduction in Na-alanine cotransport in villus cells from the chronically inflamed intestine, secondary to restoration in the affinity for the amino acid without a change in the Vmax, overview Oryctolagus cuniculus ADP + phosphate + alanine/in
-
 ?
7.4.2.2 ATP + H2O + nonpolar amino acid/out
-
 Oryctolagus cuniculus ADP + phosphate + nonpolar amino acid/in
-
 ?
7.4.2.2 ATP + H2O + nonpolar amino acid/out neutral Na-amino acid cotransport is differentially regulated by glucocorticoids in the normal and chronically inflamed rabbit small intestine, overview Oryctolagus cuniculus ADP + phosphate + nonpolar amino acid/in
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.4.2.2 ATB0
-
 Oryctolagus cuniculus