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Literature summary extracted from

  • Tumer, T.B.; Ulusoy, G.; Adali, O.; Sahin, G.; Gozdasoglu, S.; Arinc, E.
    The low frequency of defective TPMT alleles in Turkish population: a study on pediatric patients with acute lymphoblastic leukemia (2007), Am. J. Hematol., 82, 906-910.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.1.1.67 medicine patients carrying defective mutations in TMPT gene have elevated thioguanine nucleotides concentrations that finally result in severe or even fatal hematopoietic toxicities when they are treated with standard doses of 6-mercaptopurine Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.67 TPMT*2 polymorphism, single nucleotide substitution G238C, inactivating mutation Homo sapiens
2.1.1.67 TPMT*3B polymorphism, single nucleotide substitution G460A, inactivating mutation Homo sapiens
2.1.1.67 TPMT*3C polymorphism, single nucleotide substitution A719G, inactivating mutation Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.67 S-adenosyl-L-methionine + a thiopurine Homo sapiens
-
 S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.67 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.67 S-adenosyl-L-methionine + a thiopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.67 thiopurine methyltransferase
-
 Homo sapiens
2.1.1.67 TPMT
-
 Homo sapiens