EC Number | Application | Comment | Organism |
---|---|---|---|
2.1.1.67 | medicine | myelosuppression occurs in 2-7% of inflammatory bowel disease patients treated with azothioprine, and can be associated with reduced activity of thiopurine methyltransferase in some patients | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.1.1.67 | A154T/Y240C | TPMT*3A polymorphismus | Homo sapiens |
2.1.1.67 | A80P | TPMT*2 polymorphismus | Homo sapiens |
2.1.1.67 | Y240C | TPMT*3C polymorphismus | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.67 | S-adenosyl-L-methionine + a thiopurine | Homo sapiens | - |
S-adenosyl-L-homocysteine + a thiopurine S-methylether | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.67 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.1.1.67 | blood | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.67 | S-adenosyl-L-methionine + 6-mercaptopurine | azathioprine is converted via a non-enzymatic reaction to mercaptopurine, which is subsequently metabolized through TPMT | Homo sapiens | S-adenosyl-L-homocysteine + 6-methylmercaptopurine | - |
? | |
2.1.1.67 | S-adenosyl-L-methionine + a thiopurine | - |
Homo sapiens | S-adenosyl-L-homocysteine + a thiopurine S-methylether | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.1.67 | thiopurine methyltransferase | - |
Homo sapiens |