EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.20 | cathepsin G inhibitor I | - |
Homo sapiens | |
3.4.21.20 | additional information | no inhibition by von-Willebrand factor | Homo sapiens |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.20 | Ca2+ | - |
Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.20 | factor VIII + H2O | Homo sapiens | cathepsin G activates coagulation factor VIII to apartially active form, while having only a minor inactivating effect on thrombin-activated factor VIIIa, overview | factor VIIIa + peptide | - |
? | |
3.4.21.20 | factor VIIIa + H2O | Homo sapiens | cathepsin G activates coagulation factor VIII to apartially active form, while having only a minor inactivating effect on thrombin-activated factor VIIIa, inactivation occurs due to decreased stability by subsequent dissociation of the A2 subunit following proteolytic cleavage by cathepsin G, overview | factor VIII + peptide | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.20 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.21.20 | leukocyte | - |
Homo sapiens | - |
3.4.21.20 | neutrophil | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.20 | factor VIII + H2O | cathepsin G activates coagulation factor VIII to apartially active form, while having only a minor inactivating effect on thrombin-activated factor VIIIa, overview | Homo sapiens | factor VIIIa + peptide | - |
? | |
3.4.21.20 | factor VIII + H2O | cleavage releases the bound von-Willebrand factor and the corresponding peptide sequence, determination of cleavage sites, overview | Homo sapiens | factor VIIIa + peptide | - |
? | |
3.4.21.20 | factor VIIIa + H2O | - |
Homo sapiens | factor VIII + peptide | - |
? | |
3.4.21.20 | factor VIIIa + H2O | cathepsin G activates coagulation factor VIII to apartially active form, while having only a minor inactivating effect on thrombin-activated factor VIIIa, inactivation occurs due to decreased stability by subsequent dissociation of the A2 subunit following proteolytic cleavage by cathepsin G, overview | Homo sapiens | factor VIII + peptide | - |
? |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.4.21.20 | 37 | - |
assay at | Homo sapiens |