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Literature summary extracted from

  • Gale, A.J.; Rozenshteyn, D.
    Cathepsin G, a leukocyte protease, activates coagulation factor VIII (2008), Thromb. Haemost., 99, 44-51.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.20 cathepsin G inhibitor I
-
Homo sapiens
3.4.21.20 additional information no inhibition by von-Willebrand factor Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.21.20 Ca2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.20 factor VIII + H2O Homo sapiens cathepsin G activates coagulation factor VIII to apartially active form, while having only a minor inactivating effect on thrombin-activated factor VIIIa, overview factor VIIIa + peptide
-
?
3.4.21.20 factor VIIIa + H2O Homo sapiens cathepsin G activates coagulation factor VIII to apartially active form, while having only a minor inactivating effect on thrombin-activated factor VIIIa, inactivation occurs due to decreased stability by subsequent dissociation of the A2 subunit following proteolytic cleavage by cathepsin G, overview factor VIII + peptide
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.20 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.20 leukocyte
-
Homo sapiens
-
3.4.21.20 neutrophil
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.20 factor VIII + H2O cathepsin G activates coagulation factor VIII to apartially active form, while having only a minor inactivating effect on thrombin-activated factor VIIIa, overview Homo sapiens factor VIIIa + peptide
-
?
3.4.21.20 factor VIII + H2O cleavage releases the bound von-Willebrand factor and the corresponding peptide sequence, determination of cleavage sites, overview Homo sapiens factor VIIIa + peptide
-
?
3.4.21.20 factor VIIIa + H2O
-
Homo sapiens factor VIII + peptide
-
?
3.4.21.20 factor VIIIa + H2O cathepsin G activates coagulation factor VIII to apartially active form, while having only a minor inactivating effect on thrombin-activated factor VIIIa, inactivation occurs due to decreased stability by subsequent dissociation of the A2 subunit following proteolytic cleavage by cathepsin G, overview Homo sapiens factor VIII + peptide
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.20 37
-
assay at Homo sapiens