EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.73 | integrin alpha v beta3 | binds specifically to the enzyme and is required for plasminogen activation, overview | Mus musculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.73 | EDTA | inhibits binding of integrin alphanybeta3 to the enzyme | Mus musculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.73 | plasminogen + H2O | Mus musculus | the enzyme is responsible for plasminogen activation, it is also involved in cell adhesion, chemotaxis, and proliferation, the signaling events are not mediated by uPA receptor uPAR/CD87, but require the kringle domain of the enzyme, which binds integrin alphanybeta3 for induction of cell migration, e.g. of CHO cells, overview | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.73 | Mus musculus | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.73 | additional information | recombinant uPA binds purified soluble human integrin alphanybeta3, overview | Mus musculus | ? | - |
? | |
3.4.21.73 | plasminogen + H2O | - |
Mus musculus | ? | - |
? | |
3.4.21.73 | plasminogen + H2O | the enzyme is responsible for plasminogen activation, it is also involved in cell adhesion, chemotaxis, and proliferation, the signaling events are not mediated by uPA receptor uPAR/CD87, but require the kringle domain of the enzyme, which binds integrin alphanybeta3 for induction of cell migration, e.g. of CHO cells, overview | Mus musculus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.21.73 | uPA | - |
Mus musculus |
3.4.21.73 | Urokinase-type plasminogen activator | - |
Mus musculus |