Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Tarui, T.; Akakura, N.; Majumdar, M.; Andronicos, N.; Takagi, J.; Mazar, A.P.; Bdeir, K.; Kuo, A.; Yarovoi, S.V.; Cines, D.B.; Takada, Y.
    Direct interaction of the kringle domain of urokinase-type plasminogen activator (uPA) and integrin alpha v beta 3 induces signal transduction and enhances plasminogen activation (2006), Thromb. Haemost., 95, 524-534.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.73 integrin alpha v beta3 binds specifically to the enzyme and is required for plasminogen activation, overview Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.73 EDTA inhibits binding of integrin alphanybeta3 to the enzyme Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.73 plasminogen + H2O Mus musculus the enzyme is responsible for plasminogen activation, it is also involved in cell adhesion, chemotaxis, and proliferation, the signaling events are not mediated by uPA receptor uPAR/CD87, but require the kringle domain of the enzyme, which binds integrin alphanybeta3 for induction of cell migration, e.g. of CHO cells, overview ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.73 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.73 additional information recombinant uPA binds purified soluble human integrin alphanybeta3, overview Mus musculus ?
-
?
3.4.21.73 plasminogen + H2O
-
Mus musculus ?
-
?
3.4.21.73 plasminogen + H2O the enzyme is responsible for plasminogen activation, it is also involved in cell adhesion, chemotaxis, and proliferation, the signaling events are not mediated by uPA receptor uPAR/CD87, but require the kringle domain of the enzyme, which binds integrin alphanybeta3 for induction of cell migration, e.g. of CHO cells, overview Mus musculus ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.73 uPA
-
Mus musculus
3.4.21.73 Urokinase-type plasminogen activator
-
Mus musculus