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Literature summary extracted from

  • Kushiro, T.; Shibuya, M.; Ebizuka, Y.
    Cryptic regiospecificity in deprotonation step of triterpene biosynthesis catalyzed by new members of lupeol synthase (1999), Tetrahedron Lett., 40, 5553-5556.
No PubMed abstract available

Organism

EC Number Organism UniProt Comment Textmining
5.4.99.41 Arabidopsis thaliana
-
 isoform LUP1
-
5.4.99.41 Olea europaea
-
-
-
5.4.99.41 Taraxacum officinale
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.99.41 (3S)-2,3-oxidosqualene no discrimination of the terminal two methyl groups of substrate, proton abstraction occurs from both methyl groups in equal ratio. This is in contrast to Olea europea and Taraxacum officinale enzymes, which abstract the proton exclusively from (Z)-methyl of substrate Arabidopsis thaliana lupeol
-
 ?
5.4.99.41 (3S)-2,3-oxidosqualene strict discrimination of the terminal two methyl groups of substrate, proton abstraction occurs exclusively from (Z)-methyl of 2,3-oxidosqualene. Mechanism is similar in Olea europea enzyme, but not in Arabidopsis thaliana LUP1 enzyme Taraxacum officinale lupeol
-
 ?
5.4.99.41 (3S)-2,3-oxidosqualene strict discrimination of the terminal two methyl groups of substrate, proton abstraction occurs exclusively from (Z)-methyl of 2,3-oxidosqualene. Mechanism is similar in Taraxacum officinale enzyme, but not in Arabidopsis thaliana LUP1 enzyme Olea europaea lupeol
-
 ?