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Literature summary extracted from

  • Ohkubo, Y.Z.; Tajkhorshid, E.
    Distinct structural and adhesive roles of Ca2+ in membrane binding of blood coagulation factors (2008), Structure, 16, 72-81.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.21 vitamin K dependent on Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.21 membrane Ca2+ and the Gla domain are required for membrane binding by the enzyme, mechanism of Ca2+-mediated binding, molecular dynamics simulation of complex formation, overview Homo sapiens 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.21.21 Ca2+ dependent on, eight Ca2+ are bound via the Gla domain and involved in enzyme binding to the membrane with different tasks, structure and coordination, mechanism of Ca2+-mediated binding, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.21 additional information Homo sapiens membrane binding constitutes a key process in enzymatic activation of various blood coagulation factors ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.21 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.21 additional information membrane binding constitutes a key process in enzymatic activation of various blood coagulation factors Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.21 More Ca2+ and the Gla domain are required for membrane binding by the enzyme involving residues R9, R15, K18, R28, K32, R36, and K38, molecular dynamics simulation of complex formation, structure, overview Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.21.21 FVIIa
-
 Homo sapiens