EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.14.4 | 1-ethyl-3(3-dimethyl-amino-propyl)-carbodiimide*HCl | 1.0 mM inhibitor, 29% inhibition, 5.0 mM inhibitor, 64% inhibition | Capra hircus | |
3.4.14.4 | 2,2'-dithiodipyridine | 1.0 mM inhibitor, 32% inhibition, 2.5 mM inhibitor, 98% inhibition | Capra hircus | |
3.4.14.4 | 2,4,6-trinitrobenzene sufonic acid trihydrate | 1.0 mM inhibitor, 52% inhibition, 2.5 mM inhibitor, 89% inhibition | Capra hircus | |
3.4.14.4 | alpha1 anti-trypsin | 1.0 mM inhibitor, 61% inhibition | Capra hircus | |
3.4.14.4 | Aprotinin | 1.0 mM inhibitor, 59% inhibition, 5.0 mM inhibitor, 99% inhibition | Capra hircus | |
3.4.14.4 | benzamidine HCl | 1.0 mM inhibitor, 29% inhibition, 5.0 mM inhibitor, 61% inhibition | Capra hircus | |
3.4.14.4 | DTNB | 1.0 mM inhibitor, 54% inhibition, 2.5 mM inhibitor, 87% inhibition | Capra hircus | |
3.4.14.4 | EDTA | 1.0 mM inhibitor, 50% inhibition, 5.0 mM inhibitor, 64% inhibition | Capra hircus | |
3.4.14.4 | Egg white trypsin inhibitor | 1.0 mM inhibitor, 34% inhibition | Capra hircus | |
3.4.14.4 | iodoacetamide | 1.0 mM inhibitor, 27% inhibition, 5.0 mM inhibitor, 42% inhibition | Capra hircus | |
3.4.14.4 | iodoacetic acid | 1.0 mM inhibitor, 25% inhibition, 5.0 mM inhibitor, 48% inhibition | Capra hircus | |
3.4.14.4 | leupeptin | 1.0 mM inhibitor, 32% inhibition | Capra hircus | |
3.4.14.4 | N-ethylmaleimide | 1.0 mM inhibitor, 29% inhibition, 2.5 mM inhibitor, 88% inhibition, 5.0 mM inhibitor, 96% inhibition | Capra hircus | |
3.4.14.4 | N-hydroxy-succinimide | 1.0 mM inhibitor, 30% inhibition, 5.0 mM inhibitor, 51% inhibition | Capra hircus | |
3.4.14.4 | o-phenanthroline | 1.0 mM inhibitor, 46% inhibition, 2.5 mM inhibitor, 85% inhibition, 5.0 mM inhibitor, 96% inhibition | Capra hircus | |
3.4.14.4 | p-aminophenyl mercuric acetate | 1.0 mM inhibitor, 42% inhibition, 2.5 mM inhibitor, 94% inhibition | Capra hircus | |
3.4.14.4 | p-hydroxymercuriphenyl-sulfonic acid | 1.0 mM inhibitor, 22% inhibition, 2.5 mM inhibitor, 96% inhibition | Capra hircus | |
3.4.14.4 | p-nitrocatecholsulfate | 1.0 mM inhibitor, 37% inhibition, 5.0 mM inhibitor, 58% inhibition | Capra hircus | |
3.4.14.4 | Pb(CH3COO)2 | 1.0 mM inhibitor, 53% inhibition, 2.5 mM inhibitor, 97% inhibition | Capra hircus | |
3.4.14.4 | pepstatin A | 5.0 mM inhibitor, 92% inhibition | Capra hircus | |
3.4.14.4 | PMSF | 1.0 mM inhibitor, 53% inhibition, 2.5 mM inhibitor, 87% inhibition | Capra hircus | |
3.4.14.4 | puromycin | 1.0 mM inhibitor, 30% inhibition, 5.0 mM inhibitor, 58% inhibition | Capra hircus | |
3.4.14.4 | Soybean trypsin inhibitor | 1.0 mM inhibitor, 64% inhibition, 2.5 mM inhibitor, 76% inhibition | Capra hircus | |
3.4.14.4 | TLCK | 1.0 mM inhibitor, 27% inhibition, 5.0 mM inhibitor, 63% inhibition | Capra hircus | |
3.4.14.4 | TPCK | 1.0 mM inhibitor, 75% inhibition, 5.0 mM inhibitor, 88% inhibition | Capra hircus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.14.4 | 0.039 | - |
Arg-Arg-4-methoxy-beta-naphthylamide | - |
Capra hircus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.4.14.4 | 69000 | - |
determined by SDS-PAGE, gel filtration and MALDI-TOF analysis | Capra hircus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.14.4 | Capra hircus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.4.14.4 | DPP from goat brain is purified by several steps, including acid precipitation, ammonium sulfate fractionation, chromatography on a Sephadex G-100 column, cation, anion and adsorption chromatography | Capra hircus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.14.4 | brain | - |
Capra hircus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
3.4.14.4 | 0.0001 | - |
purification step, homogenate | Capra hircus |
3.4.14.4 | 0.0004 | - |
purification step, acid precipitation | Capra hircus |
3.4.14.4 | 0.0012 | - |
purification step, ammonium sulfate fractionation, 35-65% pellet | Capra hircus |
3.4.14.4 | 0.0092 | - |
purification step, gel filtration chromatography on a Sephadex G-100 column | Capra hircus |
3.4.14.4 | 0.0126 | - |
purification step, cation exchange chromatography on a CM Sephadex A-50 column | Capra hircus |
3.4.14.4 | 0.0652 | - |
purification step, anion exchange chromatography on a DEAE Sephadex A-50 column | Capra hircus |
3.4.14.4 | 0.107 | - |
purification step, adsorption chromatography on a hydroxyapatite column | Capra hircus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.14.4 | Ala-Ala-beta-naphthylamide + H2O | 10.0% activity | Capra hircus | Ala-Ala + beta-naphthylamine | - |
? | |
3.4.14.4 | Arg-Arg-4-methoxy-beta-naphthylamide + H2O | activity assay, 100% activity | Capra hircus | Arg-Arg + 4-methoxy-beta-naphthylamine | - |
? | |
3.4.14.4 | Asp-Ala-beta-naphthylamide + H2O | 0% activity | Capra hircus | Asp-Ala + beta-naphthylamine | - |
? | |
3.4.14.4 | Asp-Arg-beta-naphthylamide + H2O | 1.5% activity | Capra hircus | Asp-Arg + beta-naphthylamine | - |
? | |
3.4.14.4 | Gly-Ala-beta-naphthylamide + H2O | 3.2% activity | Capra hircus | Gly-Ala + beta-naphthylamine | - |
? | |
3.4.14.4 | Gly-Arg-beta-naphthylamide + H2O | 11.8% activity | Capra hircus | Gly-Arg + beta-naphthylamine | - |
? | |
3.4.14.4 | Gly-Phe-beta-naphthylamide + H2O | 2.4% activity | Capra hircus | Gly-Phe + beta-naphthylamine | - |
? | |
3.4.14.4 | Gly-Pro-4-methoxy-beta-naphthylamide + H2O | 0% activity | Capra hircus | Gly-Pro + 4-methoxy-beta-naphthylamine | - |
? | |
3.4.14.4 | His-Phe-beta-naphthylamide + H2O | 0% activity | Capra hircus | His-Phe + beta-naphthylamine | - |
? | |
3.4.14.4 | His-Ser-beta-naphthylamide + H2O | 0% activity | Capra hircus | His-Ser + beta-naphthylamine | - |
? | |
3.4.14.4 | Leu-Ala-beta-naphthylamide + H2O | 5.0% activity | Capra hircus | Leu-Ala + beta-naphthylamine | - |
? | |
3.4.14.4 | Lys-Ala-4-methoxy-beta-naphthylamide + H2O | 5.0% activity | Capra hircus | Lys-Ala + 4-methoxy-beta-naphthylamine | - |
? | |
3.4.14.4 | Phe-Arg-beta-naphthylamide + H2O | 17.6% activity | Capra hircus | Phe-Arg + beta-naphthylamine | - |
? | |
3.4.14.4 | Ser-Met-beta-naphthylamide + H2O | 0% activity | Capra hircus | Ser-Met + beta-naphthylamine | - |
? | |
3.4.14.4 | Ser-Tyr-beta-naphthylamide + H2O | 0% activity | Capra hircus | Ser-Tyr + beta-naphthylamine | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.4.14.4 | monomer | - |
Capra hircus |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.14.4 | dipeptidyl peptidase III | - |
Capra hircus |
3.4.14.4 | DPP III | - |
Capra hircus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.4.14.4 | 37 | - |
activity assay | Capra hircus |
EC Number | Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.4.14.4 | 40 | - |
the enzyme shows a considerable heat stability up to 40°C, 30% activity is lost at 45°C | Capra hircus |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.14.4 | 0.039 | - |
Arg-Arg-4-methoxy-beta-naphthylamide | - |
Capra hircus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.4.14.4 | 8.5 | - |
activity assay | Capra hircus |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
3.4.14.4 | 6 | 11 | the enzyme has 50% activity at pH 6 in the lower range and at pH 11 in the higher range | Capra hircus |
EC Number | Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|---|
3.4.14.4 | Capra hircus | - |
- |
4.5 |