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Literature summary extracted from

  • Haeggstroem, J.Z.; Tholander, F.; Wetterholm, A.
    Structure and catalytic mechanisms of leukotriene A4 hydrolase (2007), Prostaglandins Other Lipid Mediat., 83, 198-202.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.3.2.6 the structure of LTA4H in complex with the competitive inhibitor is determined Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.3.2.6 bestatin
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.3.2.6 Zn2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.3.2.6 (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O Homo sapiens substrate for the epoxide hydrolase reaction, in addition LTA4H shows a peptidase activity (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.6 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.6 (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O substrate for the epoxide hydrolase reaction, in addition LTA4H shows a peptidase activity Homo sapiens (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.3.2.6 leukotriene-A4 hydrolase
-
 Homo sapiens
3.3.2.6 LTA4H
-
 Homo sapiens