EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.4.24.23 | additional information | MMP-7-deficient cells do not show activation of Notch-1, which can be restored by recombinant MMP-7, phenotype, overview | Mus musculus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.4.24.23 | extracellular | - |
Mus musculus | - |
- |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.23 | Notch-1 + H2O | Mus musculus | MMP-7 interacts with the Notch pathway and is required for Notch activation, which leads to dedifferentiation of acinar cells to the nestin-positive transitional cell and further into duct-like epithelia. Besides being necessary for acinar transdifferentiation, it MMP-7 activity is sufficient to induce the process, overview | ? | - |
? | |
3.4.24.23 | Notch-1 + H2O | Mus musculus C57/BL6J | MMP-7 interacts with the Notch pathway and is required for Notch activation, which leads to dedifferentiation of acinar cells to the nestin-positive transitional cell and further into duct-like epithelia. Besides being necessary for acinar transdifferentiation, it MMP-7 activity is sufficient to induce the process, overview | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.24.23 | Mus musculus | Q10738 | C57BL/6J mice | - |
3.4.24.23 | Mus musculus C57/BL6J | Q10738 | C57BL/6J mice | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.24.23 | lacrimal gland acinar cell | - |
Mus musculus | - |
3.4.24.23 | pancreas | - |
Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.23 | Notch-1 + H2O | - |
Mus musculus | ? | - |
? | |
3.4.24.23 | Notch-1 + H2O | MMP-7 interacts with the Notch pathway and is required for Notch activation, which leads to dedifferentiation of acinar cells to the nestin-positive transitional cell and further into duct-like epithelia. Besides being necessary for acinar transdifferentiation, it MMP-7 activity is sufficient to induce the process, overview | Mus musculus | ? | - |
? | |
3.4.24.23 | Notch-1 + H2O | - |
Mus musculus C57/BL6J | ? | - |
? | |
3.4.24.23 | Notch-1 + H2O | MMP-7 interacts with the Notch pathway and is required for Notch activation, which leads to dedifferentiation of acinar cells to the nestin-positive transitional cell and further into duct-like epithelia. Besides being necessary for acinar transdifferentiation, it MMP-7 activity is sufficient to induce the process, overview | Mus musculus C57/BL6J | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.24.23 | Matrix metalloproteinase 7 | - |
Mus musculus |
3.4.24.23 | MMP-7 | - |
Mus musculus |