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Literature summary extracted from

  • Qiu, H.; Gabrielsen, A.; Agardh, H.E.; Wan, M.; Wetterholm, A.; Wong, C.H.; Hedin, U.; Swedenborg, J.; Hansson, G.K.; Samuelsson, B.; Paulsson-Berne, G.; Haeggstroem, J.Z.
    Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability (2006), Proc. Natl. Acad. Sci. USA, 103, 8161-8166.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.3.2.6 medicine LTA4H appears to be a promising target for development of drugs for prevention and treatment of atherosclerosis and its associated thrombotic complications Mus musculus
3.3.2.6 medicine LTA4H appears to be a promising target for development of drugs for prevention and treatment of atherosclerosis and its associated thrombotic complications Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.3.2.6 aminohydroxamic acid
-
Homo sapiens
3.3.2.6 aminohydroxamic acid
-
Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.3.2.6 (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O Mus musculus
-
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
-
?
3.3.2.6 (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O Homo sapiens
-
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.6 Homo sapiens
-
-
-
3.3.2.6 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.3.2.6 aorta aortic lesion Mus musculus
-
3.3.2.6 aorta aortic lesion Homo sapiens
-
3.3.2.6 atherosclerotic carotid plaque carotid atherosclerotic lesion Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.6 (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O
-
Mus musculus (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
-
?
3.3.2.6 (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O
-
Homo sapiens (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
-
?

Synonyms

EC Number Synonyms Comment Organism
3.3.2.6 leukotriene-A4 hydrolase
-
Mus musculus
3.3.2.6 leukotriene-A4 hydrolase
-
Homo sapiens
3.3.2.6 LTA4H
-
Mus musculus
3.3.2.6 LTA4H
-
Homo sapiens