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Literature summary extracted from

  • Murakami, H.; Goto, D.B.; Toda, T.; Chen, E.S.; Grewal, S.I.; Martienssen, R.A.; Yanagida, M.
    Ribonuclease activity of Dis3 is required for mitotic progression and provides a possible link between heterochromatin and kinetochore function (2007), PLoS ONE, 3, e317.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
4.6.1.19 P509L mutant contains a reduced RNase activity, the spindle-kinetochore interaction is abnormal in mutant cells, associated with mitotic arrest at a pre-anaphase stage Schizosaccharomyces pombe
4.6.1.19 T808A mutant contains a reduced RNase activity Schizosaccharomyces pombe

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.19 RNA + H2O Schizosaccharomyces pombe
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.19 Schizosaccharomyces pombe
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.19 RNA + H2O
-
 Schizosaccharomyces pombe ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.6.1.19 Dis3 ribonuclease member of the RNase II family Schizosaccharomyces pombe
4.6.1.19 ribonuclease
-
 Schizosaccharomyces pombe

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.6.1.19 7.6
-
 RNase assay Schizosaccharomyces pombe