EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.21.104 | expression of mutant enzyme R424K in CHO cells | Rattus norvegicus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.4.21.104 | additional information | construction of a truncated active enzyme form | Rattus norvegicus |
3.4.21.104 | R424K | site-directed mutagenesis, mutation at the zymogen cleavage site, yielding an active form of MASP2 that is secreted as zymogen but is more stable than wild-type MASP2, since it only autoactivates in complex with MBL upon binding to a suitable surface | Rattus norvegicus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.104 | Ca2+ | activates | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.104 | complement component C2 + H2O | Rattus norvegicus | - |
? | - |
? | |
3.4.21.104 | complement component C4 + H2O | Rattus norvegicus | - |
? | - |
? | |
3.4.21.104 | additional information | Rattus norvegicus | the enzyme is part of the lectin pathway of the complement system, it is also capable of promoting fibrinogen turnover by cleavage of prothrombin, generating thrombin | ? | - |
? | |
3.4.21.104 | plasminogen + H2O | Rattus norvegicus | activation | plasmin + propeptide of thrombin | - |
? | |
3.4.21.104 | prekallikrein + H2O | Rattus norvegicus | activation | kallikrein + propeptide of thrombin | - |
? | |
3.4.21.104 | prothrombin + H2O | Rattus norvegicus | activation of thrombin covalentyl bound to a bacterial cell surface | thrombin + propeptide of thrombin | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.104 | Rattus norvegicus | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.104 | complement component C2 + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.21.104 | complement component C4 + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.21.104 | additional information | the enzyme is part of the lectin pathway of the complement system, it is also capable of promoting fibrinogen turnover by cleavage of prothrombin, generating thrombin | Rattus norvegicus | ? | - |
? | |
3.4.21.104 | additional information | MASP2 acts in a mannan-bound MBL/MASP2 complex | Rattus norvegicus | ? | - |
? | |
3.4.21.104 | Phe-Pro-Arg-7-amido-4-methylcoumarin + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.21.104 | plasminogen + H2O | - |
Rattus norvegicus | plasmin + propeptide of thrombin | - |
? | |
3.4.21.104 | plasminogen + H2O | activation | Rattus norvegicus | plasmin + propeptide of thrombin | - |
? | |
3.4.21.104 | prekallikrein + H2O | - |
Rattus norvegicus | kallikrein + propeptide of thrombin | - |
? | |
3.4.21.104 | prekallikrein + H2O | activation | Rattus norvegicus | kallikrein + propeptide of thrombin | - |
? | |
3.4.21.104 | prothrombin + H2O | activation of thrombin covalentyl bound to a bacterial cell surface | Rattus norvegicus | thrombin + propeptide of thrombin | - |
? | |
3.4.21.104 | prothrombin + H2O | cleavage scheme, overview | Rattus norvegicus | thrombin + propeptide of thrombin | - |
? | |
3.4.21.104 | Val-Leu-Lys-7-amido-4-methylcoumarin + H2O | - |
Rattus norvegicus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.21.104 | MASP2 | - |
Rattus norvegicus |
3.4.21.104 | MBL-associated serine protease 2 | - |
Rattus norvegicus |