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Literature summary extracted from

  • Taton, M.; Ceruti, M.; Cattel, L.; Rahier, A.
    Inhibition of higher plant 2,3-oxidosqualene cyclases by nitrogen-containing oxidosqualene analogs (1996), Phytochemistry, 43, 75-81.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.4.99.39 10-aza-10,11-dihydro-2,3-oxidosqualene
-
 Pisum sativum
5.4.99.39 19-aza-18,19,22,23-tetrahydro-2,3-oxidosqualene
-
 Pisum sativum
5.4.99.39 23-aza-22,23-dihydro-2,3-oxidosqualene
-
 Pisum sativum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5.4.99.39 0.125
-
 (3S)-2,2-dimethyl-3-[(3E,7E,11E,15E)-3,7,12,16,20-pentamethylhenicosa-3,7,11,15,19-pentaen-1-yl]oxirane 30°C Pisum sativum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.4.99.39 microsome
-
 Pisum sativum
-
-

Organism

EC Number Organism UniProt Comment Textmining
5.4.99.39 Pisum sativum
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.4.99.39 cotyledon
-
 Pisum sativum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.99.39 (S)-2,3-oxidosqualene
-
 Pisum sativum beta-amyrin
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
5.4.99.39 0.015
-
-
 Pisum sativum 19-aza-18,19,22,23-tetrahydro-2,3-oxidosqualene
5.4.99.39 0.04
-
 30°C Pisum sativum 23-aza-22,23-dihydro-2,3-oxidosqualene
5.4.99.39 0.1
-
-
 Pisum sativum 10-aza-10,11-dihydro-2,3-oxidosqualene