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Literature summary extracted from
- Hormone induced expression of brush border lactase in suckling rat intestine (2008), Mol. Cell. Biochem., 312, 11-16.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.2.1.108 | cortisone | administration of cortisone to 8-day-old pups augments lactase activity | Rattus norvegicus |  |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.2.1.108 | thyroxine | administration of thyroxine to 8-day-old pups shows a decline in lactase activity | Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.2.1.108 | brush border | brush border membrane | Rattus norvegicus | 5903 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.2.1.108 | 220000 | - |
determined by SDS-PAGE and Western blot | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.2.1.108 | lactose + H2O | Rattus norvegicus | - |
D-galactose + D-glucose | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.2.1.108 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.2.1.108 | intestine | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.2.1.108 | 0.17 | - |
administration of thyroxine to 8-day-old pups, activity in suckling rat intestine | Rattus norvegicus |
| 3.2.1.108 | 0.27 | - |
control | Rattus norvegicus |
| 3.2.1.108 | 0.29 | - |
administration of insuline to 8-day-old pups, activity in suckling rat intestine | Rattus norvegicus |
| 3.2.1.108 | 0.36 | - |
administration of cortisone to 8-day-old pups, activity in suckling rat intestine | Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.2.1.108 | lactose + H2O | - |
Rattus norvegicus | D-galactose + D-glucose | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.2.1.108 | lactase | - |
Rattus norvegicus |
| 3.2.1.108 | lactase-phlorizin hydrolase | - |
Rattus norvegicus |
| 3.2.1.108 | LPH | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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