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Literature summary extracted from

  • Li, Q.; Krogmann, T.; Ali, M.A.; Tang, W.J.; Cohen, J.I.
    The amino terminus of varicella-zoster virus (VZV) glycoprotein E is required for binding to insulin-degrading enzyme, a VZV receptor (2007), J. Virol., 81, 8525-8532.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.56 expression of wild-type and mutant enzymes in Escherichia coli Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.56 E111Q site-directed mutagenesis, the mtant shows highly reduced catalytic activity compared to the wild-typ enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.56 amylin + H2O Homo sapiens degradation ?
-
 ?
3.4.24.56 amyloid beta-peptide + H2O Homo sapiens degradation ?
-
 ?
3.4.24.56 Glucagon + H2O Homo sapiens degradation ?
-
 ?
3.4.24.56 insulin + H2O Homo sapiens degradation ?
-
 ?
3.4.24.56 additional information Homo sapiens the human enzyme interacts with Varicella-zoster virus glycoprotein E, gE, facilitating viral infection and cell-to-cell spread of the virus, and thus serving as a cellular receptor for the virus, the binding region of the viral protein is located at amino acids 32 to 71 of gE, deletion of this sequence leads to loss of binding ability, overview, the secondary structure of the IDE binding domain is likely important for its interaction with IDE ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.56 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.56 amylin + H2O degradation Homo sapiens ?
-
 ?
3.4.24.56 amyloid beta-peptide + H2O degradation Homo sapiens ?
-
 ?
3.4.24.56 Glucagon + H2O degradation Homo sapiens ?
-
 ?
3.4.24.56 insulin + H2O degradation Homo sapiens ?
-
 ?
3.4.24.56 additional information the human enzyme interacts with Varicella-zoster virus glycoprotein E, gE, facilitating viral infection and cell-to-cell spread of the virus, and thus serving as a cellular receptor for the virus, the binding region of the viral protein is located at amino acids 32 to 71 of gE, deletion of this sequence leads to loss of binding ability, overview, the secondary structure of the IDE binding domain is likely important for its interaction with IDE Homo sapiens ?
-
 ?
3.4.24.56 additional information IDE has a preference for basic or hydrophobic amino acids at the carboxyl side of cleavage sites, overview, the catalytic domain of IDE is located in the amino subunit Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.24.56 More the catalytic domain of IDE is located in the amino subunit, the secondary structure of the IDE binding domain is likely important for its interaction with IDE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.24.56 IDE
-
 Homo sapiens
3.4.24.56 Insulin-degrading enzyme
-
 Homo sapiens